NSJ Bioreagents

Neutrophil Marker Antibody Overview

Neutrophil Marker Antibody detects proteins expressed in neutrophils, the most abundant circulating leukocytes in humans and a cornerstone of innate immunity. Neutrophils are first responders, arriving rapidly at infection or injury sites to destroy microbes, release cytokines, and shape immune responses. They employ multiple antimicrobial mechanisms, including phagocytosis, reactive oxygen species generation, protease release, and formation of neutrophil extracellular traps (NETs).

Markers commonly targeted by Neutrophil Marker Antibodies include CD15, CD16, CD66b, myeloperoxidase (MPO), neutrophil elastase, and lactoferrin. Each provides unique insights: CD15 for adhesion and trafficking, CD16 for Fc receptor activity, MPO for oxidative bursts, and elastase for proteolysis. By using Neutrophil Marker Antibodies, researchers can monitor neutrophil differentiation, activation, and function. Because neutrophil dysregulation underlies autoimmune disease, sepsis, and cancer, these antibodies are applied across immunology, pathology, and translational medicine.

Why Choose Neutrophil Marker Antibodies from NSJ Bioreagents?

NSJ Bioreagents supplies Neutrophil Marker Antibodies validated for IHC, immunofluorescence, western blotting, ELISA, and flow cytometry. Each antibody undergoes rigorous testing for specificity to neutrophil proteins, minimizing background and cross-reactivity with monocytes or eosinophils.

By choosing a Neutrophil Marker Antibody from NSJ Bioreagents, scientists gain reagents optimized for reproducibility. Whether analyzing inflamed tissue sections, monitoring neutrophil activation in blood, or characterizing tumor-associated neutrophils, these antibodies deliver clear, interpretable data. NSJ Bioreagents provides technical support, positive control recommendations, and application-specific protocols, ensuring confidence across diverse experimental designs.

Applications of Neutrophil Marker Antibodies

Because neutrophils participate in a wide range of biological and pathological processes, the Neutrophil Marker Antibody supports applications across many disciplines:

1) Immunology and Inflammation

Neutrophil Marker Antibodies are used to quantify neutrophil infiltration into tissues during acute and chronic inflammation.
The Neutrophil Marker Antibody helps characterize NET formation, an antimicrobial mechanism also implicated in autoimmune pathology.
Researchers use Neutrophil Marker Antibodies to study neutrophil crosstalk with macrophages, dendritic cells, and lymphocytes.

2) Infectious Disease

The Neutrophil Marker Antibody is applied in bacterial infection models, where neutrophils play critical roles in phagocytosis and microbial killing.
Neutrophil Marker Antibodies track responses to fungal pathogens such as Candida albicans and Aspergillus fumigatus.
In viral infections, the Neutrophil Marker Antibody helps determine whether neutrophils contribute to tissue damage through excessive inflammation.

3) Autoimmune and Chronic Inflammatory Disorders

Neutrophil Marker Antibodies are applied in lupus, rheumatoid arthritis, and vasculitis models, where inappropriate neutrophil activity causes tissue injury.
The Neutrophil Marker Antibody supports evaluation of therapies designed to limit neutrophil-mediated damage without impairing host defense.

4) Oncology and Tumor Microenvironment

Neutrophil Marker Antibodies identify tumor-associated neutrophils (TANs), which can either promote tumor progression or suppress it depending on context.
The Neutrophil Marker Antibody is used to study neutrophil-mediated angiogenesis, immune suppression, and metastasis.
Researchers apply Neutrophil Marker Antibodies to assess neutrophils as biomarkers predicting immunotherapy outcomes.

5) Cardiovascular and Pulmonary Disease

Neutrophil Marker Antibodies are applied to study ischemia-reperfusion injury, where neutrophils exacerbate tissue damage.
In chronic obstructive pulmonary disease (COPD) and asthma, the Neutrophil Marker Antibody helps quantify neutrophilic inflammation in airway tissue.
Neutrophil Marker Antibodies are also used to monitor vascular inflammation contributing to atherosclerosis.

6) Regenerative Medicine and Wound Healing

The Neutrophil Marker Antibody supports studies of neutrophil activity during early wound healing.
Researchers use Neutrophil Marker Antibodies to examine how neutrophil-derived factors influence angiogenesis and tissue repair.

7) Drug Discovery and Clinical Research

The Neutrophil Marker Antibody is used in translational research to test neutrophil-targeting drugs such as CXCR2 antagonists.
Neutrophil Marker Antibodies serve as tools for biomarker development in clinical trials of anti-inflammatory therapies.
In sepsis models, the Neutrophil Marker Antibody helps evaluate strategies that rebalance protective versus pathological neutrophil activity.

Why Are Neutrophil Marker Antibodies Important?

Neutrophils are vital for rapid defense against pathogens but also capable of driving pathology when overactivated. The Neutrophil Marker Antibody provides the precision needed to dissect these dual roles. By revealing where and how neutrophils operate, Neutrophil Marker Antibodies support discoveries that connect innate immunity to health and disease.

In infection biology, the Neutrophil Marker Antibody helps define how neutrophils eliminate microbes and how pathogens evade clearance. In autoimmune disorders, Neutrophil Marker Antibodies provide evidence of neutrophil-driven tissue destruction, guiding the development of targeted therapies. In oncology, the Neutrophil Marker Antibody highlights how neutrophils shape the tumor microenvironment, offering opportunities for diagnostic and therapeutic innovation.

Clinically, neutrophil activity is a prognostic marker in sepsis, COVID-19, and cancer. Neutrophil Marker Antibodies allow researchers to translate these insights into diagnostic assays and companion biomarkers. By enabling detailed study of one of the body’s most dynamic immune populations, the Neutrophil Marker Antibody links cellular biology with translational medicine.

Conclusion

Neutrophils remain indispensable defenders against infection, but their dysregulation contributes to inflammation, autoimmunity, and cancer. The Neutrophil Marker Antibody provides researchers with a reliable, specific tool for monitoring neutrophil presence, activation, and function. More broadly, Neutrophil Marker Antibodies support advancements in immunology, infectious disease, oncology, and regenerative medicine. As therapies increasingly aim to fine-tune neutrophil activity, these antibodies will continue to guide both discovery and clinical innovation.