- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PGR Antibody / Progesterone Receptor [clone PGR/3817] (V9411)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9411-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V9411-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9411SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | PGR/3817 |
| Purity | Protein A/G affinity |
| UniProt | P06401 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This PGR antibody is available for research use only. |
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Progesterone receptor (PGR) is a ligand-activated nuclear hormone receptor encoded by the PGR gene that functions as a transcription factor regulating cellular responses to progesterone signaling. PGR Antibody / Progesterone Receptor (clone PGR/3817) recognizes this steroid hormone receptor, also known as PR or Nuclear receptor subfamily 3 group C member 3 (NR3C3). Progesterone receptor is predominantly localized in the nucleus where progesterone binding activates transcriptional programs controlling endocrine signaling, reproductive tissue biology, and hormone-dependent cellular differentiation.
PGR Antibody is commonly used in studies of hormone-responsive tissues and cancers, particularly breast carcinoma where progesterone receptor expression serves as an important biomarker. PR immunohistochemistry staining is widely used in breast cancer diagnostics to evaluate progesterone receptor expression in tumor epithelial cells. Assessment of PR status by immunohistochemistry is frequently performed together with estrogen receptor (ER) and HER2 testing to determine hormone receptor status and guide therapeutic decisions in breast cancer patients.
PGR Antibody (clone PGR/3817) is a mouse monoclonal antibody designed to detect progesterone receptor expression in endocrine tissues and hormone-responsive tumors. In immunohistochemistry analysis, progesterone receptor staining typically appears as nuclear staining in epithelial cells of breast tissue and breast carcinoma. This nuclear staining pattern reflects the receptor's function as a DNA-binding transcription factor that regulates progesterone-dependent gene expression.
The PGR gene produces two major receptor isoforms, PR-A and PR-B, which arise from alternative transcription start sites and differ in their N-terminal regulatory domains. PR-B contains an additional transcriptional activation domain that enhances progesterone-responsive gene activation, while PR-A can function both as a transcriptional activator and as a regulator of PR-B signaling activity. These receptor isoforms contribute to the complex regulation of progesterone signaling in hormone-responsive tissues.
PGR Antibody supports research into steroid hormone receptor biology and hormone-dependent tumor pathways. Detection of progesterone receptor expression in breast carcinoma tissues allows researchers to examine endocrine signaling mechanisms, evaluate receptor expression patterns in tumor epithelial cells, and study hormone receptor regulation in breast cancer and related endocrine tissues.
Optimal dilution of the PGR antibody should be determined by the researcher.
A portion of amino acids 483-571 was used as the immunogen for the PGR antibody.
Aliquot the PGR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PR antibody, NR3C3 antibody, Progesterone receptor antibody, Progesterone receptor A antibody, Progesterone receptor B antibody
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