- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FUT4 Antibody / Lewis X Biosynthesis Enzyme Antibody [clone FR4A5] (V2522)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2522-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2522-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2522SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgM, kappa |
| Clone Name | FR4A5 |
| Purity | PEG precipitation |
| UniProt | P22083 |
| Localization | Cell surface and granular paranuclear |
| Applications | Flow Cytometry : 0.5-1ug/million cells Immunofluorescence : 0.5-1ug/ml |
| Limitations | This FUT4 Antibody / Lewis X Biosynthesis Enzyme Antibody is available for research use only. |
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Fucosyltransferase 4 (FUT4) is a Golgi-associated glycosyltransferase enzyme involved in biosynthesis of Lewis X (Lex/CD15) carbohydrate antigens through alpha-1,3-fucosylation of glycoconjugates and glycolipids. FUT4 participates in leukocyte-associated glycosylation pathways, cell adhesion biology, inflammatory signaling, developmental differentiation, and selectin-mediated cellular interaction networks. FUT4 Antibody is useful for investigations involving carbohydrate antigen biosynthesis, leukocyte differentiation, developmental glycobiology, and tumor-associated glycosylation regulation.
FUT4 antibody, also referred to as Fucosyltransferase 4 antibody, Lewis X biosynthesis enzyme antibody, and CD15 biosynthesis antibody in the literature, recognizes a glycosyltransferase encoded on chromosome 11q21. FUT4 localizes predominantly to Golgi-associated secretory compartments where it catalyzes formation of Lewis X-associated carbohydrate epitopes involved in leukocyte adhesion, developmental signaling, and immune-associated cell surface organization. FUT4 expression contributes directly to biosynthesis of CD15/Lewis X glycoconjugates expressed on hematopoietic, epithelial, and developmental cellular populations.
FUT4 Antibody / Lewis X Biosynthesis Enzyme Antibody (clone FR4A5) is uniquely positioned for studies involving developmental glycobiology and leukocyte-associated carbohydrate antigen biosynthesis pathways. This mouse monoclonal antibody supports detection of FUT4-associated glycosylation machinery involved in generation of Lewis X/CD15 carbohydrate determinants. Clone FR4A5 may be useful for investigations examining developmental differentiation, immune-associated glycosylation regulation, selectin ligand formation, and lineage-associated glycoconjugate organization.
FUT4-mediated glycosylation contributes to leukocyte rolling, inflammatory recruitment, embryonic development, stem cell differentiation, and epithelial-associated cell adhesion pathways. Altered FUT4 expression has been associated with hematopoietic differentiation status, inflammatory signaling activity, tumor-associated glycosylation remodeling, and cancer progression-associated carbohydrate antigen regulation. Because FUT4 is centrally involved in biosynthesis of Lewis X and CD15-associated carbohydrate structures, it serves as a useful marker for investigations involving glycoconjugate-mediated cellular signaling and developmental lineage specification.
In tissue-based and fluorescence-based detection systems, FUT4-associated expression patterns commonly correlate with cell surface-associated Lewis X/CD15 carbohydrate antigen organization and glycosylation-associated secretory activity. FUT4-dependent glycans additionally participate in selectin-mediated adhesion pathways and immune-associated cellular trafficking mechanisms. The biologic overlap between FUT4, CD15, Lewis X, and SSEA-1-associated carbohydrate epitopes supports broad utility in investigations involving developmental differentiation and leukocyte-associated glycobiology.
This FUT4 Antibody supports research involving Lewis X biosynthesis, developmental glycobiology, leukocyte differentiation pathways, carbohydrate antigen regulation, selectin-mediated adhesion biology, immune-associated glycosylation pathways, and tumor-associated glycoconjugate organization. Clone FR4A5 may be incorporated into tissue-based and cellular investigations examining FUT4-associated glycosylation networks and Lewis X/CD15 carbohydrate antigen biosynthesis in normal and diseased tissues.
For extensively published CD15 detection in Hodgkin lymphoma and leukocyte differentiation studies, see our CD15 Antibody / Leukocyte Differentiation Antigen Antibody page featuring clone Leu-M1/MMA with IHC, IF, and FACS validation data.
Optimal dilution of the FUT4 antibody should be determined by the researcher.
Myelomonocytic leukemia cells were used as the immunogen for the FUT4 antibody.
Store the FUT4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Fucosyltransferase 4 antibody, FUT4 antibody, Lewis X biosynthesis enzyme antibody, CD15 biosynthesis antibody, Alpha-(1,3)-fucosyltransferase 4 antibody
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