- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Progesterone Receptor Antibody Recombinant Rabbit MAb PGR/6854R [clone PGR/6854R] (V8885)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8885-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V8885-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8885SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PGR/6854R |
| Purity | Protein A/G affinity |
| UniProt | P06401 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Progesterone Receptor antibody is available for research use only. |
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Progesterone receptor (PGR) is a ligand-activated nuclear hormone receptor encoded by the PGR gene that functions as a transcription factor regulating cellular responses to progesterone signaling. Progesterone Receptor Antibody Recombinant Rabbit MAb PGR/6854R recognizes this steroid hormone receptor, also known as PR or Nuclear receptor subfamily 3 group C member 3 (NR3C3). Progesterone receptor is predominantly localized in the nucleus where progesterone binding activates transcriptional programs that control endocrine signaling, reproductive tissue biology, and hormone-dependent cellular differentiation.
Progesterone receptor expression is particularly important in hormone-responsive malignancies such as breast carcinoma where PR serves as a key biomarker. PR immunohistochemistry staining is widely used in breast cancer diagnostics to evaluate progesterone receptor expression in tumor epithelial cells. Determination of PR status by immunohistochemistry is commonly performed together with estrogen receptor (ER) and HER2 testing to characterize hormone receptor status and guide therapeutic decision making in breast cancer patients.
Progesterone Receptor Antibody Recombinant Rabbit MAb PGR/6854R is designed to detect PGR protein expression in studies of endocrine signaling and hormone-responsive tumor biology. In immunohistochemistry analysis, progesterone receptor staining is typically observed as nuclear staining in epithelial cells of breast tissue and breast carcinoma. This nuclear staining pattern reflects the receptor's function as a DNA-binding transcription factor that regulates progesterone-responsive gene expression.
The PGR gene produces two principal receptor isoforms, PR-A and PR-B, which arise from alternative transcription start sites and differ in their N-terminal regulatory domains. PR-B contains an additional transcriptional activation domain that enhances activation of progesterone-responsive genes, while PR-A can act both as a transcriptional activator and as a regulatory modulator of PR-B signaling activity. These isoforms contribute to the complex regulation of progesterone-dependent transcriptional responses in hormone-responsive tissues.
Progesterone Receptor Antibody Recombinant Rabbit MAb PGR/6854R supports research into steroid hormone receptor biology and breast cancer signaling pathways. Detection of progesterone receptor expression in breast carcinoma tissues allows investigators to examine hormone signaling mechanisms, evaluate receptor expression patterns in tumor cells, and study endocrine responsiveness in hormone-dependent cancers.
Optimal dilution of the Progesterone Receptor Antibody Recombinant Rabbit MAb PGR/6854R should be determined by the researcher.
A portion of amino acids 400-600 was used as the immunogen for the recombinant Progesterone Receptor antibody.
Aliquot the Progesterone Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PR antibody, PGR antibody, NR3C3 antibody, Progesterone receptor antibody, Progesterone receptor A antibody
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