- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PR Breast Cancer Antibody / Progesterone Receptor Antibody [clone PGR/8099R] (V4177)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4177-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4177-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4177SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PGR/8099R |
| Purity | Protein A/G affinity |
| UniProt | P06401 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This PR/Progesterone Receptor antibody is available for research use only. |
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Progesterone receptor (PGR) is a ligand-activated nuclear hormone receptor encoded by the PGR gene that functions as a transcription factor regulating cellular responses to progesterone signaling. PR Breast Cancer Antibody / Progesterone Receptor Antibody (clone PGR/8099R) recognizes this steroid hormone receptor, also known as Nuclear receptor subfamily 3 group C member 3 (NR3C3). Progesterone receptor is predominantly localized in the nucleus where progesterone binding activates transcriptional programs that regulate endocrine signaling, reproductive tissue biology, and hormone-dependent cellular differentiation.
PR Breast Cancer Antibody is particularly relevant in studies of hormone-responsive malignancies such as breast carcinoma where progesterone receptor expression serves as an important biomarker. PR immunohistochemistry staining is widely used in breast cancer diagnostics to evaluate progesterone receptor expression in tumor epithelial cells. Determination of PR status by immunohistochemistry is commonly performed together with estrogen receptor (ER) and HER2 testing to characterize hormone receptor status and guide therapeutic decision making in breast cancer patients.
Progesterone Receptor Antibody (clone PGR/8099R) is a recombinant rabbit monoclonal antibody designed to detect PGR protein expression in hormone-responsive tissues and tumors. In immunohistochemistry studies of breast carcinoma, progesterone receptor staining is typically observed as nuclear staining within tumor epithelial cells. This nuclear staining pattern reflects the receptor's role as a DNA-binding transcription factor that regulates progesterone-dependent gene expression in hormone-regulated tissues.
Progesterone receptor signaling plays a central role in breast tissue biology and tumor progression. Expression of PGR is frequently detected in subsets of breast carcinomas that retain hormone responsiveness. Evaluation of progesterone receptor expression is therefore an important component of breast cancer characterization, helping researchers and pathologists examine hormone signaling pathways and endocrine responsiveness of tumor cells.
PR Breast Cancer Antibody supports investigation of steroid hormone receptor biology and hormone-dependent tumor pathways. Detection of progesterone receptor expression in breast carcinoma tissues allows researchers to study endocrine signaling mechanisms, examine receptor regulation in hormone-responsive tumors, and analyze progesterone receptor expression patterns in breast cancer models and related endocrine tissues.
Optimal dilution of the PR Breast Cancer Antibody should be determined by the researcher.
A recombinant partial protein (within amino acids 1-200) from the human protein was used as the immunogen for the PR/Progesterone Receptor antibody.
Aliquot the /PRProgesterone Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PGR antibody, NR3C3 antibody, Progesterone receptor antibody, Progesterone receptor A antibody, Progesterone receptor B antibody
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