KRT17 Antibody / Keratin 17 Antibody

KRT17 Antibody Overview

KRT17 Antibody detects keratin 17, a type I intermediate filament protein expressed in nail beds, hair follicles, sebaceous glands, and activated keratinocytes. KRT17 is typically upregulated in hyperproliferative conditions, wound healing, and inflammatory skin diseases. It forms heterodimers with keratin 6 to provide resilience during epithelial stress responses.

Mutations in KRT17 cause pachyonychia congenita type 2, a rare genetic disorder characterized by thickened nails, keratoderma, and oral lesions. Beyond inherited disease, KRT17 expression is elevated in carcinomas, including cervical, breast, and basal cell cancers. The KRT17 Antibody is therefore a key tool for studying epithelial stress, genetic keratinopathies, and tumor biology.

Because keratin 17 is both a diagnostic marker and a disease-related protein, Keratin 17 Antibody reagents are used across dermatology, oncology, and regenerative medicine.

Why Choose KRT17 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers KRT17 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, ELISA, and flow cytometry. Each KRT17 Antibody is rigorously tested for specificity to keratin 17 and minimal cross-reactivity with related keratins.

By choosing a KRT17 Antibody from NSJ Bioreagents, scientists gain reagents optimized for reproducibility. Our antibodies provide sharp staining in tissue biopsies, reliable detection in protein assays, and consistent results across experimental platforms. With comprehensive datasheets, positive control recommendations, and optimized protocols, NSJ Bioreagents ensures that Keratin 17 Antibody products deliver clarity and accuracy in research and diagnostics.

Applications of KRT17 Antibodies

The KRT17 Antibody has broad utility across basic biology, clinical research, and translational studies.

1) Skin Biology and Wound Healing

• KRT17 Antibodies highlight activated keratinocytes during wound repair.

• The KRT17 Antibody supports studies of keratinocyte proliferation and differentiation.

• Keratin 17 Antibody reagents clarify cytoskeletal reorganization in epithelial stress.

2) Genetic Disorders

• Mutations in KRT17 cause pachyonychia congenita, making KRT17 Antibodies essential for research.

• The KRT17 Antibody detects keratin defects in patient-derived samples.

• Keratin 17 Antibody reagents support preclinical models of keratinopathies.

3) Dermatopathology

• KRT17 Antibodies distinguish hyperproliferative lesions from normal epithelium.

• The KRT17 Antibody helps diagnose inflammatory skin diseases such as psoriasis.

• Keratin 17 Antibody products support biomarker discovery in dermatology.

4) Oncology and Tumor Biology

• KRT17 Antibodies identify overexpression in cervical, breast, and basal cell carcinomas.

• The KRT17 Antibody is used in tumor panels to refine classification.

• Keratin 17 Antibody reagents provide biomarkers for prognosis and therapy response.

5) Nail and Hair Biology

• KRT17 Antibodies detect keratin expression in nail bed and hair follicle tissues.

• The KRT17 Antibody supports studies of hair growth and nail development.

6) Regenerative Medicine

• KRT17 Antibodies validate keratinocyte differentiation in regenerative models.

• The KRT17 Antibody ensures correct epithelial identity in engineered grafts.

7) Translational Medicine and Drug Development

• KRT17 Antibodies are applied in therapeutic testing for pachyonychia congenita.

• The KRT17 Antibody supports biomarker validation in oncology clinical trials.

• Keratin 17 Antibody reagents help assess drug effects on epithelial proliferation.

Why Are KRT17 Antibodies Important?

Keratin 17 is a stress-inducible keratin with roles in epithelial repair, genetic disease, and cancer. The KRT17 Antibody provides researchers with a precise tool for studying this protein, while Keratin 17 Antibody reagents more broadly support progress in dermatology, oncology, and regenerative medicine.

In basic biology, KRT17 Antibodies clarify epithelial stress responses. In genetics, the KRT17 Antibody helps characterize pachyonychia congenita. In oncology, Keratin 17 Antibody products are applied in cancer diagnostics and biomarker discovery.

Clinically, KRT17 markers are valuable in dermatology and oncology diagnostics, offering insights into disease mechanisms and therapeutic responses. By enabling accurate detection, the KRT17 Antibody bridges molecular biology with translational applications, advancing both research and clinical care.

Conclusion

Keratin 17 is a dynamic epithelial marker with significance in wound healing, genetic keratinopathies, and tumor biology. The KRT17 Antibody equips researchers and clinicians with a reliable tool for detecting keratin 17, while Keratin 17 Antibody reagents more broadly support discoveries in skin biology, oncology, and regenerative medicine. By linking molecular mechanisms with clinical outcomes, these antibodies remain indispensable for advancing biomedical research and improving patient health.