- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Keratin 17 Antibody Rabbit Monoclonal KRT17/7155R / Cytokeratin 17 Antibody [clone KRT17/7155R] (V8796)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8796-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V8796-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V8796SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | KRT17/7155R |
| Purity | Protein A/G affinity |
| UniProt | Q04695 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Keratin 17 antibody is available for research use only. |
|
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Keratin 17 (KRT17), also known as Cytokeratin 17 or CK17, is a type I intermediate filament protein encoded by the KRT17 gene and expressed in epithelial tissues. Keratin 17 contributes to the cytoskeletal framework of epithelial cells where keratin intermediate filaments provide structural support and mechanical resilience. Keratin 17 Antibody Rabbit Monoclonal KRT17/7155R recognizes the KRT17 protein and supports research focused on epithelial cytoskeletal organization and keratin expression in normal and disease-associated tissues.
Keratin intermediate filaments are assembled from type I and type II keratin proteins that form heterodimeric complexes within epithelial cells. These complexes polymerize into filamentous networks that extend throughout the cytoplasm, providing structural stability and maintaining cellular architecture. Keratin 17 participates in these filament networks and contributes to epithelial cell integrity and resistance to mechanical stress.
KRT17 expression is commonly detected in basal epithelial layers of stratified epithelia and in epithelial appendages such as hair follicles and glandular structures. Cytokeratin 17 expression can also be observed in epithelial cells involved in regenerative or proliferative processes. Because keratin expression patterns vary across epithelial tissues, keratin profiling has become a widely used approach for studying epithelial differentiation and tissue lineage.
Cytokeratin 17 has been extensively investigated in cancer research due to its association with epithelial tumors. Expression of KRT17 protein has been reported in several epithelial malignancies, where cytokeratin expression patterns can provide insight into tumor differentiation and epithelial lineage. Detection of CK17 is frequently used in studies examining tumor biology and epithelial cytoskeletal remodeling during malignant transformation.
As a member of the keratin intermediate filament family, Keratin 17 plays a role in maintaining epithelial tissue structure and supporting intracellular organization. Intermediate filaments composed of keratin proteins function alongside actin filaments and microtubules to maintain cytoskeletal stability and cellular morphology.
Keratin 17 Antibody Rabbit Monoclonal KRT17/7155R is a rabbit monoclonal antibody developed to detect KRT17 protein in research samples. Detection of Keratin 17 using this antibody supports investigations of epithelial cytoskeletal organization, epithelial differentiation, and keratin expression patterns in biological research.
Optimal dilution of the Keratin 17 Antibody Rabbit Monoclonal KRT17/7155R should be determined by the researcher.
Recombinant full-length human KRT17 protein was used as the immunogen for the Keratin 17 antibody.
Aliquot the Keratin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Keratin 17 Antibody Rabbit Monoclonal KRT17/7155R | V8796 NSJ Bioreagents
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