- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Keratin 17 Antibody Recombinant Rabbit MAb KRT17/8346R / Cytokeratin 17 Antibody [clone KRT17/8346R] (V4494)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4494-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4494-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4494SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT17/8346R |
| Purity | Protein A/G affinity |
| UniProt | Q04695 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant Keratin 17 antibody is available for research use only. |
|
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Keratin 17 (KRT17), also known as Cytokeratin 17 or CK17, is a type I intermediate filament protein encoded by the KRT17 gene and expressed primarily in epithelial tissues. Keratin 17 is a structural component of the cytoskeletal network that contributes to mechanical stability, epithelial integrity, and cellular architecture. Keratin 17 Antibody Recombinant Rabbit MAb KRT17/8346R recognizes the KRT17 protein and supports research focused on epithelial cytoskeletal biology and keratin filament organization.
Keratin proteins form heterodimeric intermediate filaments composed of type I and type II keratin pairs that assemble into complex cytoskeletal networks within epithelial cells. Keratin 17 commonly associates with type II keratins to form intermediate filament structures that help maintain epithelial cell structure and resilience against mechanical stress. These keratin networks are essential for maintaining epithelial tissue architecture and cellular stability.
KRT17 expression is commonly observed in basal epithelial layers of stratified epithelia, including structures such as the epidermis and epithelial appendages. Keratin 17 can also be detected in epithelial cells of certain glandular tissues where intermediate filament networks contribute to cytoskeletal organization. Because keratin proteins are cell-type specific, their expression patterns are frequently used to study epithelial differentiation and tissue structure.
Keratin 17 expression has also been widely investigated in cancer research, as cytokeratin expression patterns often reflect epithelial lineage and differentiation status of tumor cells. Detection of KRT17 protein is frequently used in studies examining epithelial tumors and the cytoskeletal characteristics of malignant cells. Evaluation of keratin expression profiles can provide insights into epithelial tumor biology and cellular differentiation states.
The KRT17 protein belongs to the large keratin family of intermediate filament proteins, which together form the structural framework of epithelial cells. Intermediate filaments composed of keratin proteins provide tensile strength to epithelial tissues and support intracellular organization. Because of their structural role, keratins represent essential markers for studying epithelial cell biology and cytoskeletal architecture.
Keratin 17 Antibody Recombinant Rabbit MAb KRT17/8346R is a recombinant rabbit monoclonal antibody developed to detect KRT17 protein in research applications. Detection of keratin 17 using this antibody supports studies examining epithelial cytoskeletal organization, epithelial differentiation, and keratin expression patterns in normal and disease-associated tissues.
Optimal dilution of the Keratin 17 Antibody Recombinant Rabbit MAb KRT17/8346R should be determined by the researcher.
A recombinant fragment of human KRT17 protein was used as the immunogen for the recombinant Keratin 17 antibody.
Aliquot the Keratin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Cytokeratin 17 antibody, CK17 antibody, Keratin 17 antibody, KRT17 antibody
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