- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cytokeratin 17 Antibody for IHC / CK17 Antibody (KRT17) [clone MSVA-117R] (V6094)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V6094-100UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 654.50 | |
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V6094-20UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 324.50 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MSVA-117R |
| UniProt | Q04695 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Cytokeratin 17/CK17 antibody is available for research use only. |
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Cytokeratin 17 (KRT17), also known as CK17 or Keratin 17, is a type I intermediate filament protein encoded by the KRT17 gene and expressed primarily in epithelial cells. Cytokeratin 17 participates in the structural cytoskeleton of epithelial tissues and contributes to mechanical stability and cellular organization within stratified and glandular epithelia. Cytokeratin 17 Antibody for IHC / CK17 Antibody (KRT17) is designed for immunohistochemistry-based detection of cytokeratin 17 in formalin-fixed, paraffin-embedded tissues, enabling visualization of epithelial cell populations within histologic sections.
Immunohistochemistry analysis of cytokeratin proteins is widely used to examine epithelial differentiation and tissue architecture. Cytokeratin 17 Antibody for IHC allows researchers and pathologists to detect CK17 expression directly within tissue sections, where the protein typically produces cytoplasmic staining within epithelial cells due to its role as a cytoskeletal intermediate filament. The antibody therefore enables visualization of CK17-positive epithelial structures while preserving the morphological context of the surrounding tissue.
Cytokeratin 17 expression is commonly observed in basal epithelial layers of stratified epithelia and in specific glandular epithelial tissues. Immunohistochemistry staining patterns frequently reveal CK17 expression in epithelial structures of the skin, hair follicles, and other epithelial surfaces where intermediate filament networks contribute to epithelial integrity. Detection of CK17 by immunohistochemistry therefore provides insight into epithelial cell differentiation and structural organization within tissues.
Immunohistochemical analysis of CK17 has also been widely used in cancer research because cytokeratin expression patterns often reflect epithelial lineage and tumor differentiation status. Visualization of cytokeratin 17 within tumor tissues can highlight epithelial tumor cell populations while maintaining architectural context within the tumor microenvironment. Cytokeratin 17 Antibody for IHC therefore supports studies examining epithelial tumor biology and epithelial differentiation patterns in malignant tissues.
Tissue microarray immunohistochemistry analysis using Cytokeratin 17 Antibody for IHC (clone MSVA-117R) demonstrates staining patterns across large panels of normal and cancer tissues. In these analyses, CK17 staining is detected within epithelial compartments of tissues consistent with reported expression patterns. The distribution of staining observed in tissue arrays corresponds with cytokeratin 17 expression profiles reported in gene expression datasets and publicly available resources including the Human Protein Atlas.
Cytokeratin 17 Antibody for IHC / CK17 Antibody (KRT17) (clone MSVA-117R) is a recombinant rabbit monoclonal antibody developed for immunohistochemistry applications targeting cytokeratin 17 protein. By enabling clear visualization of CK17-positive epithelial cells in FFPE tissues, this antibody supports studies investigating epithelial differentiation, tissue architecture, and cytokeratin expression patterns in both normal and cancer tissues.
1. Optimal dilution of the Cytokeratin 17 Antibody for IHC antibody should be determined by the researcher.
2. This KRT17/Keratin 17 antibody is recombinantly produced by expression in human HEK293 cells.
3. Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121oC in pH 7.8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:150 at 37oC for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer's directions.
A recombinant fragment of human KRT17 protein (exact sequence is proprietary) was used as the immunogen for the Cytokeratin 17/CK17 antibody.
Cytokeratin 17/CK17 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
Cytokeratin 17 antibody, CK17 antibody, Keratin 17 antibody, KRT17 antibody
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