NSJ Bioreagents

Cytokeratin 17 Antibody Overview

Cytokeratin 17 antibody products are widely used to study epithelial differentiation, basal keratinocyte biology, and hyperproliferative epithelial states. Cytokeratin 17 (KRT17) is a type I intermediate filament protein expressed primarily in basal and reserve epithelial cell populations, where it contributes to cytoskeletal organization, cellular integrity, and epithelial stress responses. KRT17 expression is particularly associated with activated keratinocytes, regenerative epithelial compartments, and tumor-associated epithelial remodeling.

Cytokeratin 17 antibody, also referred to as KRT17 antibody and CK17 antibody in the literature, is commonly utilized in pathology and cancer research to characterize squamous differentiation patterns, basal-like epithelial phenotypes, and proliferative epithelial lesions. KRT17 expression is frequently elevated in squamous cell carcinomas, cervical carcinoma, pancreatic ductal adenocarcinoma, and other aggressive epithelial malignancies, making Cytokeratin 17 antibody a valuable tool for diagnostic pathology and translational oncology research.

Biological Role of Cytokeratin 17

Cytokeratin 17 belongs to the keratin intermediate filament family that provides structural support to epithelial cells. Unlike differentiation-associated keratins expressed in mature suprabasal epithelium, KRT17 is strongly linked to proliferative epithelial compartments and activated epithelial repair programs. Its expression increases during wound healing, inflammatory skin disorders, and epithelial stress signaling.

KRT17 also participates in signaling pathways that influence cellular proliferation, immune modulation, and epithelial growth responses. Studies have demonstrated that KRT17 can regulate inflammatory cytokine expression, interact with intracellular signaling mediators, and contribute to tumor-associated epithelial plasticity. These functions have expanded interest in Cytokeratin 17 antibody beyond structural biology into cancer progression and epithelial inflammatory signaling research.

Within stratified epithelia, KRT17 expression is often concentrated in basal cell layers and reserve epithelial populations. In pathology applications, Cytokeratin 17 antibody can help distinguish basal-like tumor phenotypes and identify aggressive epithelial subtypes with enhanced proliferative capacity.

Applications of Cytokeratin 17 Antibody

Cytokeratin 17 antibody products are widely used across epithelial biology, dermatology, oncology, and diagnostic pathology applications.

Epithelial and Basal Cell Biology

Cytokeratin 17 antibody supports investigation of basal keratinocyte differentiation and epithelial regenerative responses.

KRT17 antibodies help characterize epithelial progenitor compartments and hyperproliferative epithelial states.

Cancer and Tumor Pathology

Cytokeratin 17 antibody is frequently utilized in studies of squamous differentiation and epithelial tumor progression.

KRT17 expression patterns are commonly evaluated in carcinomas displaying basal-like or aggressive epithelial phenotypes.

Inflammation and Stress Responses

Cytokeratin 17 antibody supports research into epithelial stress signaling and inflammatory epithelial remodeling.

KRT17 is associated with activated epithelial repair programs in injured or inflamed tissue environments.

Why Choose Cytokeratin 17 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Cytokeratin 17 antibody products for research applications involving epithelial biology, cancer pathology, and keratinocyte differentiation studies. Our antibody portfolio includes reagents suitable for detecting KRT17 expression in epithelial tissues, cultured cells, and translational research models.

This Cytokeratin 17 antibody page is part of a broader Cytokeratin antibody panel used to study epithelial differentiation, tissue distribution, and tumor classification across multiple keratin family members.

Researchers studying keratinocyte activation, epithelial structural organization, and intermediate filament dynamics may also be interested in our Cell Biology Antibodies landing page featuring adhesion proteins, intracellular markers, and signaling related targets.

Browse the complete collection of research antibodies on our Antibodies landing page.

<p>Cytokeratin 17 IHC Antibody Cervical Carcinoma. Immunohistochemistry analysis of FFPE human cervical carcinoma tissue using Cytokeratin 17 IHC Antibody clone <a href="../tds/cytokeratin-17-antibody-ctkn17-1-v7128">CTKN17-1</a> demonstrates strong HRP-DAB brown cytoplasmic staining in malignant epithelial cell populations. The staining pattern is consistent with the established expression of Cytokeratin 17 / CK17 / KRT17 in stratified epithelial tissues and proliferative epithelial-derived malignancies, highlighting tumor-associated keratin intermediate filament organization and basal-like epithelial differentiation. Heat-induced epitope retrieval was performed by boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 minutes followed by cooling at room temperature prior to antibody incubation.</p>

Cytokeratin 17 IHC Antibody Cervical Carcinoma. Immunohistochemistry analysis of FFPE human cervical carcinoma tissue using Cytokeratin 17 IHC Antibody clone CTKN17-1 demonstrates strong HRP-DAB brown cytoplasmic staining in malignant epithelial cell populations. The staining pattern is consistent with the established expression of Cytokeratin 17 / CK17 / KRT17 in stratified epithelial tissues and proliferative epithelial-derived malignancies, highlighting tumor-associated keratin intermediate filament organization and basal-like epithelial differentiation. Heat-induced epitope retrieval was performed by boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 minutes followed by cooling at room temperature prior to antibody incubation.