NSJ Bioreagents

KRT14 Antibody Overview

KRT14 Antibody detects keratin 14, a type I intermediate filament protein expressed in basal keratinocytes of stratified epithelia. Together with keratin 5, KRT14 forms heterodimers that build the cytoskeletal framework of the basal epidermal layer, providing resilience to mechanical stress and anchoring basal cells to the basement membrane.

Mutations in KRT14 cause epidermolysis bullosa simplex (EBS), a blistering skin disorder characterized by extreme fragility of the epidermis. Beyond genetic disease, aberrant KRT14 expression has been reported in basal cell carcinoma, squamous cell carcinoma, and specific subtypes of breast and oral cancers. The KRT14 Antibody therefore serves as both a basic research tool and a clinically relevant diagnostic reagent.

Keratin 14 Antibody reagents are widely applied in dermatology, oncology, and regenerative medicine, making them indispensable for understanding basal cell biology and its disruption in disease.

Why Choose KRT14 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides KRT14 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, ELISA, and flow cytometry. Each KRT14 Antibody is rigorously tested for specificity to keratin 14, ensuring minimal cross-reactivity with related keratins such as KRT15 or KRT5.

By selecting a KRT14 Antibody from NSJ Bioreagents, researchers gain reagents optimized for reproducibility. Our antibodies provide strong, precise staining of basal keratinocytes, reliable detection in protein assays, and robust results across applications. With detailed datasheets, recommended controls, and validated protocols, NSJ Bioreagents ensures that Keratin 14 Antibody products provide dependable performance in both basic and clinical research.

Applications of KRT14 Antibodies

The KRT14 Antibody has broad applications across dermatology, oncology, and cell biology.

1) Skin Biology and Development

KRT14 Antibodies highlight basal keratinocytes in stratified epithelia.
The KRT14 Antibody clarifies epidermal stratification and renewal.
Keratin 14 Antibody reagents support developmental studies of epithelial differentiation.

2) Genetic Disorders

KRT14 Antibodies detect mutations causing epidermolysis bullosa simplex.
The KRT14 Antibody is used to study keratin defects in patient biopsies and models.
Keratin 14 Antibody products help define mechanisms of keratin-related fragility.

3) Dermatopathology

KRT14 Antibodies are applied to distinguish basal cell carcinoma from other tumors.
The KRT14 Antibody highlights basal keratinocyte origin in tumor pathology.
Keratin 14 Antibody reagents support diagnosis of keratinization disorders.

4) Oncology and Tumor Biology

KRT14 Antibodies are used in breast cancer research to identify basal-like subtypes.
The KRT14 Antibody supports studies of oral and squamous cell carcinomas.
Keratin 14 Antibody products contribute to biomarker discovery and therapy response analysis.

5) Wound Healing and Stress Response

KRT14 Antibodies track basal keratinocyte activation in wound repair.
The KRT14 Antibody helps clarify epithelial response to mechanical stress.

6) Regenerative Medicine

KRT14 Antibodies validate basal epithelial identity in stem cell-derived tissues.
The KRT14 Antibody supports tissue engineering models of stratified epithelium.

7) Translational Medicine and Clinical Trials

KRT14 Antibodies are used in biomarker validation for keratin-related diseases.
The KRT14 Antibody supports precision medicine by linking keratin expression to therapy outcomes.
Keratin 14 Antibody reagents are applied in oncology trials to refine patient stratification.

Why Are KRT14 Antibodies Important?

Keratin 14 is a defining basal keratin that underpins skin stability and disease. The KRT14 Antibody provides precise detection of this protein, while Keratin 14 Antibody reagents more broadly support dermatology, oncology, and regenerative medicine.

In basic research, KRT14 Antibodies highlight basal keratinocyte biology and stratification. In genetics, the KRT14 Antibody helps clarify epidermolysis bullosa simplex mechanisms. In oncology, Keratin 14 Antibody products are valuable in tumor classification and biomarker discovery.

Clinically, KRT14 expression is a marker for basal-like tumors and keratin-related diseases, making the KRT14 Antibody a powerful diagnostic and prognostic tool. By linking molecular detection to patient outcomes, these antibodies remain indispensable for advancing dermatology and oncology research.

Conclusion

Keratin 14 is a basal epithelial marker critical for skin stability, genetic disease, and oncology. The KRT14 Antibody equips researchers and clinicians with a reliable tool for studying keratin 14 expression, while Keratin 14 Antibody reagents more broadly support progress in dermatology, regenerative biology, and cancer research. By connecting molecular mechanisms with clinical applications, these antibodies remain essential for biomedical discovery and improved healthcare outcomes.