- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Wilms Tumor 1 Antibody / WT1 [clone 6F-H2] (V2930)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2930-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V2930-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V2930SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 | |
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V2930IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Rat |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 6F-H2 |
| Purity | Protein G affinity chromatography |
| UniProt | P19544 |
| Localization | Nuclear, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Wilms Tumor 1 antibody is available for research use only. |
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Wilms Tumor 1 antibody clone 6F-H2 is a monoclonal antibody that detects WT1, a zinc finger transcription factor originally identified in Wilms tumor, a pediatric kidney malignancy. WT1 regulates genes involved in development, differentiation, and survival, particularly in kidney, gonads, and hematopoietic tissues. NSJ Bioreagents provides this antibody as a high-quality reagent for oncology, hematology, and developmental biology research.
The antibody produces strong nuclear staining in tissues where WT1 is expressed, including podocytes of the kidney and mesothelial cells. In diagnostic pathology, WT1 detection is widely used to identify Wilms tumor, mesotheliomas, and certain leukemias. It supports differentiation of these tumors from morphologically similar neoplasms and provides valuable information in tumor classification panels.
In oncology, WT1 antibody clone 6F-H2 has been applied to studies of tumor biology and prognosis. WT1 overexpression has been linked to aggressive forms of leukemia, ovarian carcinoma, and mesothelioma. This antibody enables detailed assessment of WT1 expression patterns, supporting both experimental models and clinical research.
In developmental biology, WT1 is studied for its critical role in kidney and gonadal formation. Detecting WT1 helps map transcriptional programs during embryogenesis and contributes to understanding congenital syndromes affecting genitourinary development.
The antibody has also been used in immunotherapy research, as WT1 peptides are being explored as targets for cancer vaccines. Reliable detection of WT1 expression ensures appropriate selection of tumor models for therapeutic development.
Validated in tissue-based and cell-based systems, the antibody consistently produces specific nuclear staining with minimal background. Alternate names include WT1 antibody, Wilms tumor suppressor protein antibody, and zinc finger protein WT1 antibody.
Optimal dilution of the Wilms Tumor 1 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A recombinant protein corresponding to residues 1-181 from the human protein was used as the immunogen for the Wilms Tumor 1 antibody.
Store the Wilms Tumor 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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