KRT20 Antibody / Keratin 20 Antibody

KRT20 Antibody Overview

KRT20 Antibody detects keratin 20, a type I intermediate filament protein expressed primarily in gastrointestinal epithelium, urothelium, and Merkel cells of the skin. KRT20 is commonly found in gastric mucosa, intestinal mucosa, and certain epithelial tumors. Together with other keratins, it contributes to cytoskeletal organization, tissue stability, and epithelial polarity.

KRT20 is widely used in diagnostic pathology, particularly in distinguishing gastrointestinal and urothelial carcinomas from tumors of other epithelial origins. The KRT20+/KRT7− profile, for example, is a classic immunohistochemical signature used to differentiate colorectal carcinomas from adenocarcinomas of the lung, breast, or ovary. The KRT20 Antibody is therefore indispensable in tumor classification, gastrointestinal biology, and translational oncology.

Because KRT20 expression patterns are altered in disease and cancer, Keratin 20 Antibody reagents are highly valuable in both research and clinical applications.

Why Choose KRT20 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers KRT20 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, ELISA, and flow cytometry. Each KRT20 Antibody undergoes rigorous validation to confirm specificity for keratin 20 while minimizing cross-reactivity with related keratins.

By selecting a KRT20 Antibody from NSJ Bioreagents, researchers gain access to reagents optimized for reproducibility. Our antibodies provide strong, specific staining in gastrointestinal tissues, consistent detection in protein assays, and robust results across platforms. With comprehensive datasheets, positive control recommendations, and optimized protocols, NSJ Bioreagents ensures that Keratin 20 Antibody products support both discovery and clinical research with clarity and confidence.

Applications of KRT20 Antibodies

The KRT20 Antibody has extensive applications in research, diagnostics, and translational medicine.

1) Gastrointestinal Biology

• KRT20 Antibodies identify intestinal epithelial cells and goblet cells.

• The KRT20 Antibody helps distinguish gastrointestinal mucosa from other epithelial tissues.

• Keratin 20 Antibody reagents support studies of epithelial differentiation in the GI tract.

2) Oncology and Tumor Classification

• KRT20 Antibodies are critical for distinguishing colorectal carcinomas from other adenocarcinomas.

• The KRT20 Antibody is applied in immunohistochemical panels with KRT7 for tumor origin profiling.

• Keratin 20 Antibody tools support biomarker discovery in gastrointestinal cancers.

3) Urothelial and Skin Biology

• KRT20 Antibodies detect urothelial cells and Merkel cells in skin.

• The KRT20 Antibody is applied in bladder cancer diagnostics.

• Keratin 20 Antibody reagents support studies of skin mechanoreceptors.

4) Development and Differentiation

• KRT20 Antibodies are used to investigate epithelial lineage specification.

• The KRT20 Antibody highlights differentiation markers during embryonic development.

5) Regenerative Medicine

• KRT20 Antibodies validate intestinal epithelial differentiation from stem cells.

• The KRT20 Antibody ensures correct lineage specification in regenerative models.

6) Translational Medicine and Clinical Trials

• KRT20 Antibodies support biomarker validation in gastrointestinal and bladder cancers.

• The KRT20 Antibody is used in clinical research to correlate expression with therapy outcomes.

• Keratin 20 Antibody products support precision oncology strategies.

Why Are KRT20 Antibodies Important?

Keratin 20 is a distinctive epithelial marker with critical roles in gastrointestinal and urothelial biology as well as in oncology. The KRT20 Antibody provides accurate detection of this keratin, while Keratin 20 Antibody reagents more broadly empower discoveries in cancer classification, epithelial differentiation, and regenerative biology.

In basic science, KRT20 Antibodies clarify gastrointestinal differentiation and epithelial polarity. In diagnostic pathology, the KRT20 Antibody helps distinguish colorectal cancer from other adenocarcinomas. In translational research, Keratin 20 Antibody tools provide biomarkers for precision oncology and therapy development.

Clinically, the KRT20 immunostaining profile remains a gold standard in tumor diagnostics. By ensuring accurate detection, the KRT20 Antibody connects molecular biology to patient outcomes, advancing progress in cancer diagnostics and personalized medicine.

Conclusion

Keratin 20 is a key epithelial marker with applications in gastrointestinal biology, urothelial research, and cancer diagnostics. The KRT20 Antibody equips researchers and clinicians with a dependable tool for detecting keratin 20 expression, while Keratin 20 Antibody reagents more broadly support research in pathology, oncology, and regenerative medicine. By linking basic biology with clinical applications, these antibodies remain essential for advancing both discovery science and patient care.