- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Keratin 20 Antibody Recombinant Rabbit MAb KRT20/4879R / CK20/Cytokeratin 20 Antibody [clone KRT20/4879R] (V9328)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9328-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9328-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9328SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT20/4879R |
| Purity | Protein A/G affinity |
| UniProt | P35900 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 2-4ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Keratin 20 antibody is available for research use only. |
|
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Keratin 20 (KRT20) is a type I acidic cytokeratin that belongs to the epithelial intermediate filament family responsible for maintaining cytoskeletal stability and structural integrity in epithelial cells. Keratin 20 is localized primarily within the cytoplasm of epithelial cells where it participates in intermediate filament networks that provide mechanical support and maintain epithelial tissue architecture. Keratin 20 Antibody Recombinant Rabbit MAb KRT20/4879R recognizes Cytokeratin 20 and enables detection of this epithelial cytoskeletal protein in research studies examining epithelial differentiation, epithelial cell identity, and cytoskeletal organization.
Keratin 20 is encoded by the KRT20 gene located on chromosome 17q21 within a genomic cluster containing multiple keratin genes involved in epithelial cytoskeletal organization. The protein is widely known in the literature as Cytokeratin 20 or CK20, two commonly used synonyms in epithelial biology and cancer research. Keratin 20 forms heterodimers with type II keratins such as keratin 8, and these dimers polymerize to generate intermediate filament networks that extend throughout the cytoplasm. These filament structures help stabilize epithelial cells and maintain the mechanical resilience of tissues exposed to continuous mechanical stress.
Keratin 20 expression is strongly associated with differentiated epithelial cell populations. High expression is observed in intestinal epithelial cells, gastric mucosa, and urothelial umbrella cells. Because of this restricted distribution pattern, Cytokeratin 20 antibody reagents are frequently used as markers for epithelial lineage identification. Detection of KRT20 protein therefore supports research examining epithelial differentiation, epithelial tissue development, and epithelial organization.
In cancer biology, Keratin 20 expression is frequently retained in tumors derived from gastrointestinal and urothelial epithelia. CK20 expression is commonly detected in colorectal carcinoma, gastric carcinoma, pancreatic carcinoma, and bladder carcinoma, where it serves as a marker of epithelial differentiation. Detection of Cytokeratin 20 assists research studies investigating epithelial tumor biology, epithelial cytoskeletal organization, and differentiation states within tumor cells.
The recombinant rabbit monoclonal antibody clone KRT20/4879R targets Keratin 20 and can be used to detect KRT20 protein in research applications involving epithelial cytoskeletal proteins. Detection of Cytokeratin 20 supports studies examining epithelial differentiation pathways, epithelial tissue organization, and epithelial tumor biology.
Optimal dilution of the Keratin 20 Antibody Recombinant Rabbit MAb KRT20/4879R should be determined by the researcher.
A portion of amino acids 196-323 was used as the immunogen for the recombinant Keratin 20 antibody.
Aliquot the Keratin 20 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Cytokeratin 20 antibody, CK20 antibody, KRT20 antibody, Cytokeratin-20 antibody, Keratin 20 protein antibody
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