NSJ Bioreagents

KRT5 Antibody Overview

KRT5 Antibody detects keratin 5, a type II intermediate filament protein expressed in basal epithelial cells. KRT5 pairs with keratin 14 to form structural filaments that provide mechanical stability in the epidermis and other stratified epithelia. This keratin is essential for maintaining basal cell integrity, supporting keratinocyte proliferation, and ensuring resilience of skin against stress.

Mutations in the KRT5 gene are linked to epidermolysis bullosa simplex (EBS), a blistering disorder characterized by fragile skin. Beyond genetic disease, aberrant KRT5 expression is observed in cancers such as basal cell carcinoma, squamous cell carcinoma, and specific subtypes of breast and lung cancers. The KRT5 Antibody is thus a versatile reagent applied in dermatology, oncology, and regenerative medicine.

Because of its central role in basal cells, Keratin 5 Antibody tools are used to study development, disease, and epithelial regeneration.

Why Choose KRT5 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides KRT5 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, ELISA, and flow cytometry. Each KRT5 Antibody undergoes stringent validation to confirm specificity for keratin 5 and minimize cross-reactivity with other keratins.

By selecting a KRT5 Antibody from NSJ Bioreagents, scientists gain reagents optimized for reproducibility. Our antibodies deliver strong basal cell staining in tissue sections, reliable protein detection in lysates, and consistent results across assays. With detailed datasheets, recommended controls, and validated protocols, NSJ Bioreagents ensures that Keratin 5 Antibody products provide dependable, high-quality results in both research and clinical settings.

Applications of KRT5 Antibodies

The KRT5 Antibody is widely applied in dermatology, oncology, and translational biology.

1) Skin Biology and Development

KRT5 Antibodies identify basal keratinocytes in the epidermis.
The KRT5 Antibody highlights epithelial organization and renewal in stratified epithelia.
Keratin 5 Antibody reagents support studies of keratinocyte proliferation and differentiation.

2) Genetic Disorders

KRT5 Antibodies are used to investigate epidermolysis bullosa simplex.
The KRT5 Antibody detects mutation effects in patient biopsies and model systems.
Researchers apply Keratin 5 Antibody tools to clarify mechanisms of keratin-related fragility.

3) Dermatopathology

KRT5 Antibodies distinguish basal cell carcinoma from other skin tumors.
The KRT5 Antibody is used in histopathology to confirm basal cell identity.
Keratin 5 Antibody reagents aid in diagnosing blistering disorders and keratinization defects.

4) Oncology and Tumor Biology

KRT5 Antibodies are applied in breast cancer research to define basal-like subtypes.
The KRT5 Antibody supports lung cancer diagnostics, distinguishing squamous from adenocarcinoma.
Keratin 5 Antibody reagents are used to identify biomarkers predictive of tumor aggressiveness.

5) Regenerative Medicine

KRT5 Antibodies validate basal cell identity in stem cell-derived epithelial cultures.
The KRT5 Antibody is applied in tissue engineering to confirm stratified epithelial structure.

6) Translational Medicine and Drug Discovery

KRT5 Antibodies are used in clinical trials for keratin-targeted therapies.
The KRT5 Antibody supports biomarker discovery and validation in oncology and dermatology.
Keratin 5 Antibody products help evaluate drug effects on epithelial regeneration.

Why Are KRT5 Antibodies Important?

Keratin 5 is a critical structural and functional protein in basal epithelial cells. The KRT5 Antibody provides researchers with a precise means to study this keratin, while Keratin 5 Antibody reagents more broadly support discoveries in skin biology, oncology, and regenerative research.

In basic research, KRT5 Antibodies highlight epithelial renewal and stratification. In pathology, the KRT5 Antibody supports diagnosis of genetic keratinopathies and cancers. In oncology, Keratin 5 Antibody products help classify tumor subtypes and predict therapy response.

Clinically, KRT5 is a reliable marker of basal-like breast and lung cancers, and its detection aids in diagnosis and therapeutic decisions. By providing accurate measurement, the KRT5 Antibody links molecular biology to patient outcomes, advancing both discovery science and precision medicine.

Conclusion

Keratin 5 is a basal epithelial protein central to skin integrity, disease, and cancer. The KRT5 Antibody equips researchers and clinicians with a dependable tool for detecting keratin 5, while Keratin 5 Antibody reagents more broadly support advances in dermatology, oncology, and translational medicine. By bridging basic science with clinical application, these antibodies remain indispensable for biomedical discovery and improved healthcare outcomes.