- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cytokeratin 5/6 antibody detects keratins 5 and 6, intermediate filament proteins encoded by the KRT5 and KRT6 genes. These keratins are expressed in basal epithelial cells and stratified squamous epithelia, where they contribute to structural stability and resilience. Because keratins 5 and 6 are widely used as diagnostic markers in pathology, particularly for distinguishing squamous cell carcinomas from adenocarcinomas, Cytokeratin 5/6 antibody is a critical reagent in oncology and epithelial biology.
Keratin 5 is a type II keratin that pairs with keratin 14, while keratin 6 is a type II keratin upregulated in hyperproliferative states such as wound healing and psoriasis. Together, keratins 5 and 6 form filament networks that maintain cytoskeletal integrity and provide mechanical support against stress. Aberrant expression patterns of these keratins are associated with disease progression in cancer and dermatological conditions.
The Cytokeratin 5/6 antibody clone KRT5.6/2090 provides specific and reproducible detection of these basal keratins. Clone KRT5.6/2090 has been cited in peer-reviewed studies on carcinoma classification, tumor progression, and skin pathology. Its reproducibility supports applications in immunohistochemistry and diagnostic panels, where accurate epithelial lineage identification is crucial.
Research using clone KRT5.6/2090 has shown how cytokeratin 5/6 expression helps define squamous differentiation in lung carcinomas and basal-like breast cancers. In dermatology, detection of keratin 6 highlights regenerative activity in skin injury and chronic inflammatory disease. This antibody provides a foundation for both diagnostic pathology and mechanistic studies of epithelial biology.
NSJ Bioreagents provides this Cytokeratin 5/6 antibody to support oncology, pathology, and epithelial research. Alternate names include KRT5 antibody, KRT6 antibody, keratin type II cytoskeletal 5 antibody, keratin type II cytoskeletal 6 antibody, basal cell keratin antibody, squamous differentiation marker antibody, and epithelial intermediate filament antibody.
Optimal dilution of the Cytokeratin 5/6 antibody should be determined by the researcher.
Recombinant full-length human KRT5 protein was used as the immunogen for the Cytokeratin 5/6 antibody.
Store the Cytokeratin 5/6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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