- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IL-6 Antibody [clone MP5-20F3] (V2346)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2346-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
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V2346-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
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V2346SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Species Reactivity | Mouse |
| Format | Purified |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG1, kappa |
| Clone Name | MP5-20F3 |
| Purity | Protein G purified IL-6 antibody |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 16193 |
| Localization | Cytoplasmic and extracellular (secreted) |
| Applications | Neutralization Studies (order BSA/sodium Azide-free Format) : Flow Cytometry : 0.5-1ug/10^6 cells Immunofluorescence : 0.5-1ug/ml |
| Limitations | This IL-6 antibody is available for research use only. |
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IL-6 antibody clone MP5-20F3 is a monoclonal antibody that detects interleukin 6, a multifunctional cytokine involved in immune regulation, inflammation, and hematopoiesis. IL-6 is produced by a wide range of cells, including monocytes, fibroblasts, endothelial cells, and T lymphocytes, in response to infections, injuries, or stress. It plays central roles in acute phase responses, B cell maturation, and T cell differentiation. Dysregulated IL-6 signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. NSJ Bioreagents provides IL-6 antibody clone MP5-20F3 as a reliable reagent for studying cytokine biology and disease pathogenesis.
IL-6 antibody clone MP5-20F3 produces strong cytoplasmic staining in activated immune and stromal cells. In immunology research, this antibody is used to investigate IL-6 driven pathways that shape adaptive immune responses. IL-6 promotes B cell maturation into antibody-producing plasma cells and influences the balance of T helper cell subsets, including the differentiation of Th17 cells, which are implicated in autoimmunity.
In inflammatory disease studies, IL-6 antibody clone MP5-20F3 has been widely applied to understand how sustained IL-6 production contributes to conditions such as rheumatoid arthritis, Crohn disease, and systemic lupus erythematosus. Elevated IL-6 levels correlate with disease severity, making this antibody valuable for identifying and tracking cytokine expression in tissues and experimental models.
In oncology, IL-6 antibody clone MP5-20F3 has been employed to explore how IL-6 promotes tumor progression. IL-6 supports tumor growth by stimulating angiogenesis, enhancing survival signaling, and driving chronic inflammation in the tumor microenvironment. Detection of IL-6 has been particularly important in cancers such as multiple myeloma and lung carcinoma, where IL-6 contributes to therapy resistance and poor prognosis.
IL-6 antibody clone MP5-20F3 is also useful in metabolic and neurobiology research. Chronic IL-6 signaling has been linked to insulin resistance, obesity, and neuroinflammation, underscoring its broad impact on human disease.
This antibody has been validated in tissue-based and cell-based studies, consistently producing reproducible results. It is widely cited across immunology, oncology, and inflammation-related research. Alternate names include interleukin 6 antibody, B cell differentiation factor antibody, and hybridoma growth factor antibody.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the IL-6 antibody to be titered up or down for optimal performance.
Recombinant mouse IL-6 protein was used as the immunogen for this antibody.
Store the IL-6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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