Cytokeratin 2 Antibody / CK2 Antibody

Cytokeratin 2 Antibody Overview

Cytokeratin 2 Antibody reagents target keratin 2 (KRT2), a type II intermediate filament protein expressed in the upper spinous and granular layers of the epidermis. Partnering with keratin 10, KRT2 provides structural integrity to differentiating keratinocytes and contributes to the barrier properties of skin. Its highly tissue-specific expression makes it a reliable marker of epidermal differentiation.

Mutations in KRT2 are associated with ichthyosis bullosa of Siemens (IBS), a rare inherited skin disorder characterized by blistering and scaling. Because of its restricted expression and involvement in skin diseases, the Cytokeratin 2 Antibody is indispensable in dermatology, epidermal biology, and pathology. The CK2 Antibody also supports applications in developmental research, regenerative medicine, and translational studies.

Why Choose Cytokeratin 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers Cytokeratin 2 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each Cytokeratin 2 Antibody undergoes stringent quality control to ensure specificity, reproducibility, and minimal background staining.

By selecting Cytokeratin 2 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and reliability. Our antibodies provide strong staining in epidermal tissues, reproducible protein detection in lysates, and robust performance across platforms. Comprehensive datasheets, recommended controls, and validated protocols ensure reproducibility in both discovery and diagnostic settings.

Applications of Cytokeratin 2 Antibodies

The Cytokeratin 2 Antibody supports a wide range of dermatology, pathology, and developmental applications.

1) Dermatology and Skin Biology

• Cytokeratin 2 Antibodies highlight expression in the granular layer of the epidermis.

• The Cytokeratin 2 Antibody supports studies of keratinocyte differentiation.

• CK2 Antibody reagents clarify epidermal structure and barrier function.

2) Genetic Skin Disorders

• Cytokeratin 2 Antibodies identify KRT2 mutations linked to ichthyosis bullosa of Siemens.

• The Cytokeratin 2 Antibody supports research into skin fragility syndromes.

• CK2 Antibody reagents validate biomarkers for hereditary keratinopathies.

3) Oncology and Tumor Biology

• Cytokeratin 2 Antibodies help classify squamous cell carcinomas.

• The Cytokeratin 2 Antibody provides epithelial lineage confirmation in tumor biopsies.

• CK2 Antibody reagents support biomarker discovery in oncology research.

4) Developmental and Stem Cell Biology

• Cytokeratin 2 Antibodies track epidermal lineage specification during embryogenesis.

• The Cytokeratin 2 Antibody validates differentiation in stem cell and organoid models.

• CK2 Antibody tools support regenerative research on epithelial repair.

5) Inflammation and Immune Response

• Cytokeratin 2 Antibodies highlight keratinocyte activation during chronic skin inflammation.

• The Cytokeratin 2 Antibody supports research into skin barrier dysfunction in inflammatory disease.

6) Translational and Clinical Research

• Cytokeratin 2 Antibodies are validated in biomarker-driven dermatology studies.

• The Cytokeratin 2 Antibody contributes to diagnostic workflows in pathology.

• CK2 Antibody reagents provide reproducibility in translational and clinical studies.

Why Are Cytokeratin 2 Antibodies Important?

KRT2 is a key differentiation-associated keratin in the epidermis. The Cytokeratin 2 Antibody enables precise detection of this protein, while the CK2 Antibody extends its applications across diagnostics, dermatology, and translational medicine.

In skin biology, Cytokeratin 2 Antibodies highlight keratinocyte maturation and barrier formation. In genetic disorders, the Cytokeratin 2 Antibody helps study ichthyosis bullosa of Siemens and related keratinopathies. In oncology, CK2 Antibody reagents support classification of squamous cell carcinomas.

Clinically, accurate detection of KRT2 ensures diagnostic confidence in skin pathology and supports patient care in inherited keratin disorders. Cytokeratin 2 Antibodies bridge discovery research with clinical application, ensuring reproducibility and reliability.

Conclusion

Cytokeratin 2 is a differentiation-associated keratin with critical roles in epidermal biology and disease. The Cytokeratin 2 Antibody equips researchers and clinicians with validated reagents for detecting KRT2 in dermatology, pathology, and oncology, while the CK2 Antibody provides complementary applications in developmental biology and translational medicine. By ensuring specificity and reproducibility, these antibodies remain essential for advancing keratin research and improving diagnostic outcomes.