Cytokeratin 14 Antibody / CK14 Antibody

Cytokeratin 14 Antibody Overview

Cytokeratin 14 Antibody reagents target keratin 14 (KRT14), a type I intermediate filament protein expressed in basal keratinocytes of stratified squamous epithelia. KRT14 pairs with keratin 5 to form heterodimers that stabilize the cytoskeleton, provide mechanical strength, and support tissue integrity. Its expression is critical for epidermal development, repair, and cellular homeostasis.

Mutations in KRT14 are linked to epidermolysis bullosa simplex (EBS), a blistering skin disorder caused by structural fragility of basal keratinocytes. KRT14 expression is also elevated in squamous cell carcinomas, basal-like breast cancers, and other epithelial malignancies. The Cytokeratin 14 Antibody is therefore an essential tool in dermatology, oncology, and developmental biology, while the CK14 Antibody supports translational medicine and diagnostic pathology.

Why Choose Cytokeratin 14 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers Cytokeratin 14 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, ELISA, and flow cytometry. Each Cytokeratin 14 Antibody undergoes strict validation to ensure specificity, reproducibility, and minimal background staining.

By selecting Cytokeratin 14 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for reliability and clarity. Our antibodies provide strong staining in basal epithelia, reproducible detection in protein lysates, and dependable results across experimental platforms. Detailed datasheets, suggested controls, and validated protocols further ensure reproducibility in research and diagnostic settings.

Applications of Cytokeratin 14 Antibodies

The Cytokeratin 14 Antibody supports broad applications across skin biology, oncology, and pathology.

1) Dermatology and Skin Biology

• Cytokeratin 14 Antibodies detect KRT14 expression in basal keratinocytes.

• The Cytokeratin 14 Antibody clarifies keratinocyte architecture and cytoskeletal stability.

• CK14 Antibody reagents support studies of wound repair and epidermal resilience.

2) Genetic Skin Disorders

• Cytokeratin 14 Antibodies identify mutations causing epidermolysis bullosa simplex.

• The Cytokeratin 14 Antibody supports research into genetic skin fragility syndromes.

• CK14 Antibody reagents validate biomarkers for inherited keratinopathies.

3) Oncology and Tumor Biology

• Cytokeratin 14 Antibodies are key markers for basal-like breast cancers and squamous cell carcinomas.

• The Cytokeratin 14 Antibody supports tumor classification in pathology workflows.

• CK14 Antibody reagents validate biomarkers in cancer progression and therapy response.

4) Pathology and Diagnostics

• Cytokeratin 14 Antibodies confirm basal epithelial lineage in biopsies.

• The Cytokeratin 14 Antibody supports diagnostic panels used in epithelial tumor classification.

• CK14 Antibody reagents provide clarity in distinguishing basal from suprabasal lineages.

5) Developmental and Stem Cell Biology

• Cytokeratin 14 Antibodies highlight basal epithelial progenitors in embryonic development.

• The Cytokeratin 14 Antibody validates keratin expression in organoid and stem cell models.

• CK14 Antibody reagents support regenerative medicine studies on epithelial repair.

6) Translational and Clinical Research

• Cytokeratin 14 Antibodies are used in biomarker-driven clinical studies.

• The Cytokeratin 14 Antibody contributes to patient stratification in precision oncology.

• CK14 Antibody reagents provide reproducibility in translational workflows.

Why Are Cytokeratin 14 Antibodies Important?

KRT14 is a defining marker of basal epithelial keratinocytes, critical for structural integrity and disease classification. The Cytokeratin 14 Antibody enables precise detection of this protein, while the CK14 Antibody expands applications across pathology, oncology, and translational medicine.

In dermatology, Cytokeratin 14 Antibodies highlight basal keratinocyte stability and genetic skin disorders. In oncology, the Cytokeratin 14 Antibody is an essential biomarker for basal-like breast cancers and squamous cell carcinomas. In developmental biology, CK14 Antibody reagents validate epithelial differentiation and lineage fidelity.

Clinically, detection of KRT14 provides diagnostic confidence in skin disorders and epithelial tumors. Cytokeratin 14 Antibodies ensure reproducibility and reliability, bridging laboratory discovery with clinical application.

Conclusion

Cytokeratin 14 is a basal epithelial keratin with vital roles in skin integrity, cancer biology, and pathology. The Cytokeratin 14 Antibody equips scientists and clinicians with validated reagents for detecting KRT14 in dermatology, oncology, and developmental research, while the CK14 Antibody provides complementary applications in translational medicine. By ensuring specificity and reproducibility, these antibodies remain indispensable for advancing keratin research and improving clinical outcomes.