AQP4 Antibody / Aquaporin 4 Antibody

AQP4 Antibody Overview

AQP4 Antibody reagents target aquaporin 4, the most abundant water channel in the central nervous system. AQP4 is localized to astrocytic endfeet at the blood–brain barrier and ependymal lining of the ventricles, where it regulates water flux between brain tissue and cerebrospinal fluid. This unique distribution positions AQP4 as a central regulator of brain water homeostasis.

One of AQP4’s most striking roles is in the glymphatic system, a clearance pathway responsible for removing metabolic waste and proteins such as amyloid-β and tau from the brain. Dysregulation of AQP4 is implicated in impaired waste clearance, edema after stroke and trauma, and the pathogenesis of neurodegenerative diseases. Because of these essential roles, the AQP4 Antibody is a key reagent for studying neurovascular biology, brain injury, and neurodegeneration. The Aquaporin 4 Antibody complements these efforts with validated tools across multiple research platforms.

Why Choose AQP4 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides AQP4 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and ELISA. Each AQP4 Antibody undergoes extensive validation for specificity, reproducibility, and performance across neuroscience workflows.

By choosing AQP4 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and reliability. Our antibodies consistently produce strong detection in brain sections, robust signals in lysates, and dependable results across translational studies. Comprehensive datasheets, validated controls, and optimized protocols ensure reproducibility from basic research to clinical applications.

Applications of AQP4 Antibodies

The AQP4 Antibody supports wide-ranging applications in brain physiology, pathology, and translational medicine.

1) Stroke and Ischemia Research

• AQP4 Antibodies highlight roles in brain edema after ischemia.

• The AQP4 Antibody supports studies of astrocytic swelling and neuroprotection.

• Aquaporin 4 Antibody reagents validate biomarkers for stroke therapy.

2) Glymphatic System and Waste Clearance

• AQP4 Antibodies detect perivascular expression critical for clearance of amyloid-β and tau.

• The AQP4 Antibody supports studies of sleep-dependent clearance mechanisms.

• Aquaporin 4 Antibody reagents provide biomarkers for neurodegeneration research.

3) Traumatic Brain Injury (TBI)

• AQP4 Antibodies identify altered expression following trauma.

• The AQP4 Antibody supports research into edema management after injury.

• Aquaporin 4 Antibody reagents contribute to translational brain injury models.

4) Neurodegenerative Disease

• AQP4 Antibodies clarify roles in Alzheimer’s and Parkinson’s pathology.

• The AQP4 Antibody supports studies of protein aggregation clearance.

• Aquaporin 4 Antibody reagents extend applications into aging and dementia biology.

5) Neurovascular and Blood–Brain Barrier Studies

• AQP4 Antibodies detect astrocytic endfoot localization at the blood–brain barrier.

• The AQP4 Antibody supports studies of ion and water transport in neurovascular units.

• Aquaporin 4 Antibody reagents validate biomarkers for barrier integrity.

6) Translational and Clinical Research

• AQP4 Antibodies are integrated into biomarker-driven studies of stroke and neurodegeneration.

• The AQP4 Antibody supports diagnostics for NMO, edema, and dementia.

• Aquaporin 4 Antibody reagents ensure reproducibility in translational pipelines.

Why Are AQP4 Antibodies Important?

AQP4 is a central regulator of brain water balance and waste clearance. The AQP4 Antibody equips researchers with validated tools for studying stroke, edema, and neurodegeneration, while the Aquaporin 4 Antibody broadens these applications into translational and clinical research.

In stroke research, AQP4 Antibodies highlight its role in edema formation and therapy development. In glymphatic biology, the AQP4 Antibody clarifies mechanisms of waste clearance and links to neurodegenerative disease. In neurovascular studies, Aquaporin 4 Antibody reagents support investigations of barrier integrity and astrocytic function.

Clinically, AQP4 is a biomarker for neuromyelitis optica (NMO), stroke prognosis, and dementia progression. Reliable AQP4 Antibodies ensure reproducibility, bridging fundamental discoveries with diagnostic and therapeutic pipelines.

Conclusion

AQP4 is a pivotal aquaporin for regulating brain water flux, waste clearance, and edema formation. The AQP4 Antibody provides validated reagents for stroke, glymphatic clearance, and neurodegenerative research, while the Aquaporin 4 Antibody expands applications across clinical and translational pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing neuroscience and improving outcomes in brain health.