Aquaporin Antibodies / AQP Antibodies

Aquaporin Antibodies Overview

Aquaporin Antibodies target the aquaporin family of water channel proteins, which regulate the transport of water and small solutes across cell membranes. Aquaporins (AQPs) are integral to maintaining fluid balance, cell volume regulation, and osmotic homeostasis in tissues ranging from the kidney and salivary glands to the brain and lungs.

There are at least 13 known mammalian aquaporins (AQP0–AQP12), each with specialized tissue distributions and physiological roles. For example, AQP1 facilitates water movement in red blood cells and renal tubules, AQP2 regulates water reabsorption in the collecting ducts of the kidney, and AQP4 is critical in astrocytic end-feet at the blood–brain barrier. Because aquaporin dysfunction is linked to disorders such as diabetes insipidus, brain edema, glaucoma, and cancer, the Aquaporin Antibodies portfolio provides crucial tools for basic, translational, and clinical research. The AQP Antibodies category complements these studies with broad coverage of the entire protein family.

Why Choose Aquaporin Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Aquaporin Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, ELISA, and flow cytometry. Each Aquaporin Antibody undergoes rigorous validation to ensure high specificity, reproducibility, and performance across multiple assay systems.

By choosing Aquaporin Antibodies from NSJ Bioreagents, scientists gain reagents optimized for clarity and consistency. Our antibodies deliver strong staining in tissue sections such as kidney, brain, and lung, reproducible protein detection in lysates, and robust performance across discovery and translational applications. Comprehensive datasheets, validated controls, and optimized protocols support reproducibility across diverse research pipelines.

Applications of Aquaporin Antibodies

The Aquaporin Antibodies collection supports diverse applications in fluid regulation, neuroscience, and translational medicine.

1) Renal Physiology and Kidney Disorders

• Aquaporin Antibodies detect AQP1, AQP2, and AQP3 in renal tubules.

• The Aquaporin Antibodies support studies of water reabsorption and diabetes insipidus.

• AQP Antibodies validate renal biomarkers in translational nephrology research.

2) Neuroscience and Brain Function

• Aquaporin Antibodies detect AQP4 in astrocytes at the blood–brain barrier.

• The Aquaporin Antibodies support studies of cerebral edema and neuromyelitis optica.

• AQP Antibodies clarify astrocytic regulation of water balance in the CNS.

3) Ophthalmology and Vision Research

• Aquaporin Antibodies highlight roles of AQP0 in lens transparency.

• The Aquaporin Antibodies support studies of glaucoma and retinal water balance.

• AQP Antibodies validate ocular biomarkers in vision research.

4) Pulmonary and Salivary Gland Biology

• Aquaporin Antibodies detect AQP5 in salivary glands and respiratory epithelium.

• The Aquaporin Antibodies support studies of fluid secretion and airway hydration.

• AQP Antibodies clarify roles in respiratory disease and cystic fibrosis.

5) Cancer and Tumor Biology

• Aquaporin Antibodies highlight dysregulated AQP expression in tumor cells.

• The Aquaporin Antibodies support studies of proliferation, migration, and metastasis.

• AQP Antibodies provide biomarkers for oncology and translational research.

6) Translational and Clinical Research

• Aquaporin Antibodies are integrated into biomarker-driven studies of kidney and brain disease.

• The Aquaporin Antibody supports diagnostics in nephrology and neurology.

• AQP Antibodies ensure reproducibility across translational medicine pipelines.

Why Are Aquaporin Antibodies Important?

Aquaporins regulate essential physiological processes by controlling water and solute movement across membranes. The Aquaporin Antibodies portfolio equips scientists with validated reagents to study their roles in homeostasis, disease, and therapy.

In nephrology, Aquaporin Antibodies highlight renal water reabsorption and fluid balance. In neuroscience, they reveal AQP4’s role in blood–brain barrier function and pathology. In oncology, AQP Antibodies uncover cancer-related changes in aquaporin expression.

Clinically, aquaporins are biomarkers and therapeutic targets in conditions ranging from brain edema to kidney disease. Reliable Aquaporin Antibodies ensure reproducibility, bridging fundamental biology with translational and clinical research.

Conclusion

Aquaporins are key regulators of water homeostasis across tissues and organs. The Aquaporin Antibodies collection provides validated reagents for research in nephrology, neuroscience, ophthalmology, oncology, and beyond. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing fluid biology and improving clinical outcomes.