- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Melan-A Antibody / Melanocyte Lineage Marker [clone A103] (V2121)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2121-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2121-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2121SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V2121IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | A103 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 2315 |
| Localization | Cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Melan-A Antibody / Melanocyte Lineage Marker clone A103 is available for research use only, not for diagnostic or therapeutic testing. |
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Melan-A (MLANA), also known as MART-1, is a melanocyte lineage-associated protein involved in melanosome biogenesis, melanocytic differentiation, and pigmentation-associated cellular pathways. Melan-A Antibody / Melanocyte Lineage Marker clone A103 is suitable for investigations involving melanoma biology, melanocytic differentiation, pigment cell signaling pathways, and dermatopathology-associated tumor research. Melan-A is predominantly expressed within normal melanocytes and melanocytic tumors, where it contributes to melanosome structure and melanocyte-associated differentiation programs.
Melan-A antibody, also referred to as MLANA antibody, MART-1 antibody, Melanocyte differentiation antigen antibody, and Clone A103 Melan-A antibody in the literature, recognizes a melanocyte-associated protein widely used as a lineage marker in melanoma pathology and melanocytic tumor research. Expression of Melan-A is strongly associated with melanocytic cells and melanoma-derived tumors, making it an important biomarker for studies involving melanocyte differentiation and pigment cell-associated neoplasms. The protein is primarily localized within melanosome-associated intracellular compartments, consistent with its role in melanin-producing cell biology.
Melanocytic lineage markers such as Melan-A are central components of dermatopathology and melanoma-associated tumor classification studies. Melan-A expression has been widely investigated in cutaneous melanoma, metastatic melanoma, melanocytic nevi, and pigment cell differentiation-associated signaling pathways. Because melanocyte lineage-associated proteins contribute to melanosome biology and pigmentation pathways, Melan-A remains relevant for investigations involving melanocyte development, melanoma progression, and melanocytic tumor biology.
Clone A103 is a highly cited mouse monoclonal antibody with extensive use in peer-reviewed melanoma and dermatopathology research literature. This clone has been widely utilized in studies involving melanocytic tumor identification, melanoma-associated lineage analysis, and melanocyte differentiation pathways. The extensive publication history associated with clone A103 supports its continued relevance for melanoma pathology, pigment cell biology, and melanocyte lineage-associated investigations.
Immunohistochemistry and western blot analyses support detection of endogenous Melan-A expression in melanocytic tissue and melanoma-derived samples, consistent with the expected localization pattern of this melanocyte lineage-associated protein. HuProt(TM) protein microarray specificity validation further supports selective recognition of Melan-A among thousands of human proteins. The combined validation profile supports use of clone A103 for investigations involving melanoma biology, melanocyte differentiation, pigment-associated signaling pathways, and dermatopathology-associated tumor research.
An antibody targeting Melan-A can therefore support studies involving melanoma pathology, melanocyte lineage identification, pigment cell differentiation pathways, melanosome-associated biology, and melanocytic tumor-associated signaling mechanisms.
Explore our MART-1 / Melan-A Antibody page to discover additional antibodies for melanoma biology, melanocyte lineage identification, pigment cell differentiation, and dermatopathology research applications.
Due to differences in protocols and secondary antibody used, the Melan-A Antibody / Melanocyte Lineage Marker clone A103 may require titration for optimal performance.
1. FFPE staining is enhanced by boiling sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant human protein was used as the immunogen for the Melan-A antibody.
Store the Melan-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Melan-A antibody, MLANA antibody, MART-1 antibody, Melanocyte differentiation antigen antibody, Clone A103 Melan-A antibody
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