ACE2 Antibody / Angiotensin I Converting Enzyme 2 Antibody

ACE2 Antibody Overview

ACE2 Antibody reagents target angiotensin I converting enzyme 2 (ACE2), a membrane-bound carboxypeptidase that counterbalances the renin–angiotensin system (RAS) and serves as the cellular entry receptor for coronaviruses such as SARS-CoV and SARS-CoV-2.

ACE2’s enzymatic function involves cleaving angiotensin II into angiotensin-(1–7), which has vasodilatory and anti-inflammatory properties. By opposing the vasoconstrictive effects of ACE, ACE2 protects against hypertension, heart failure, and fibrotic injury. Its distribution in the lungs, heart, kidneys, intestines, and vascular endothelium underlies its wide-ranging physiological impact.

ACE2 gained particular prominence during the COVID-19 pandemic as the gateway for SARS-CoV-2 infection. Viral spike proteins bind directly to ACE2, enabling entry into host cells. This dual role—cardiovascular regulation and viral receptor—makes the ACE2 Antibody indispensable for both fundamental and translational research. The Angiotensin I Converting Enzyme 2 Antibody complements these applications by ensuring reproducibility across experimental platforms.

Why Choose ACE2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides ACE2 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes thorough validation to confirm specificity, reproducibility, and reliability.

Key advantages:

• Broad Assay Coverage: Validated across major immunoassays.

• Cross-Tissue Relevance: Effective in lung, heart, kidney, and vascular tissue.

• Batch Consistency: Ensures reproducibility across long-term studies.

• Detailed Support: Protocols, recommended controls, and validation images included.

• Translational Applications: From discovery to diagnostics and therapy development.

By choosing NSJ Bioreagents, researchers gain confidence that the ACE2 Antibody delivers clarity and consistency in cardiovascular, infectious disease, and translational research.

Applications of ACE2 Antibodies

The ACE2 Antibody supports diverse applications spanning cardiovascular biology, infectious disease, inflammation, and translational pipelines.

1) COVID-19 and Virology

• Detect ACE2 as the receptor for SARS-CoV-2 spike protein.

• Support research into tissue-specific viral susceptibility.

• Provide biomarkers for disease severity and viral entry.

• Extend into therapeutic development for antivirals and vaccines.

2) Pulmonary Biology

• ACE2 Antibody detects alveolar epithelial cell expression.

• Supports studies of lung injury, acute respiratory distress syndrome (ARDS), and fibrosis.

• Clarifies protective roles of ACE2 in lung inflammation.

• Provides translational biomarkers for respiratory research.

3) Cardiovascular Regulation

• Detect ACE2 expression in myocardium and vascular endothelium.

• Support studies of heart failure, hypertension, and vascular remodeling.

• Provide biomarkers for protective angiotensin-(1–7) pathways.

• Extend into translational cardiology and therapeutic pipelines.

4) Renal and Fluid Balance

• ACE2 Antibody detects expression in renal proximal tubules.

• Supports research into sodium regulation and diabetic nephropathy.

• Provides biomarkers for chronic kidney disease.

• Extends into nephrology and translational research.

5) Inflammation and Immunology

• Detect ACE2 modulation during cytokine storm and systemic inflammation.

• Support studies linking ACE2 to immune regulation.

• Provide biomarkers for inflammatory and autoimmune research.

• Extend into translational immunology.

6) Gastrointestinal and Metabolic Research

• ACE2 Antibody detects intestinal expression tied to nutrient absorption.

• Supports research into metabolic disease, including obesity and diabetes.

• Provides biomarkers for gut–immune–metabolic interactions.

• Extends into translational endocrinology and gastroenterology.

7) Neurology and Cerebrovascular Biology

• Detect ACE2 expression in brain vascular endothelium.

• Support studies of neurovascular regulation and stroke.

• Provide biomarkers for ACE2’s protective role in cerebrovascular injury.

• Extend into translational neuroscience.

8) Pharmacology and Therapeutics

• ACE2 is a target for recombinant ACE2 therapies and ACE2 modulators.

• Antibodies support drug validation in preclinical models.

• Provide biomarkers for drug efficacy and safety.

• Extend into antiviral and cardiovascular drug pipelines.

9) Translational and Clinical Research

• ACE2 Antibody supports biomarker-driven diagnostics for COVID-19 and cardiovascular disease.

• Provides reproducibility for clinical trial assays.

• Links laboratory discovery with translational and clinical outcomes.

• Ensures reliability in diagnostics and personalized medicine.

Why Are ACE2 Antibodies Important?

ACE2 is a unique protein bridging cardiovascular physiology and viral infection. The ACE2 Antibody equips researchers with validated tools to investigate these dual roles in health and disease.

In infectious disease, it provides essential reagents for SARS-CoV-2 and coronavirus biology. In cardiology, it clarifies ACE2’s protective role against hypertension and heart failure. In pulmonology, it highlights ACE2’s role in ARDS and lung inflammation. In nephrology, it supports research into kidney health and chronic disease.

Clinically, ACE2 is both a biomarker and therapeutic target. Reliable Angiotensin I Converting Enzyme 2 Antibody reagents ensure reproducibility, linking laboratory studies with diagnostics, therapeutics, and personalized medicine.

Conclusion

ACE2 is a membrane carboxypeptidase central to vascular regulation, renal physiology, lung protection, and viral infection. The ACE2 Antibody provides validated tools for infectious disease, cardiovascular, renal, and translational research, while the Angiotensin I Converting Enzyme 2 Antibody complements these applications across assay platforms. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing discovery and clinical medicine.