Angiotensin I Converting Enzyme 2 Antibody / ACE2 Antibody

Angiotensin I Converting Enzyme 2 Antibody Overview

Angiotensin I Converting Enzyme 2 Antibody reagents target ACE2, a homolog of angiotensin-converting enzyme (ACE) with distinct biological functions. Unlike ACE, which generates angiotensin II, ACE2 primarily converts angiotensin II into angiotensin-(1–7), a peptide with vasodilatory, anti-inflammatory, and antifibrotic properties. By counterbalancing the effects of ACE, ACE2 serves as a protective regulator of cardiovascular and renal physiology.

ACE2 is expressed in multiple tissues, including lungs, heart, kidneys, intestines, and brain. Beyond its roles in the renin–angiotensin system, ACE2 gained international attention as the functional receptor for SARS-CoV-2, the virus responsible for COVID-19. Viral entry is mediated by the binding of the spike protein to ACE2 on host cells, followed by priming through TMPRSS2. This discovery positioned ACE2 not only as a critical cardiovascular regulator but also as a central player in viral pathogenesis.

Because of its dual importance in physiology and infectious disease, the Angiotensin I Converting Enzyme 2 Antibody is indispensable for cardiovascular biology, renal physiology, and virology. The ACE2 Antibody complements this research by offering reproducible detection across multiple assay formats.

Why Choose Angiotensin I Converting Enzyme 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Angiotensin I Converting Enzyme 2 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes strict validation to ensure specificity, reproducibility, and compatibility with diverse applications.

Benefits include:

• Assay Versatility: Validated across multiple research platforms.

• Pathway Relevance: Direct detection of ACE2, critical for cardiovascular and viral biology.

• Batch-to-Batch Consistency: Ensures reproducible results across studies.

• Detailed Technical Data: Each antibody is supplied with datasheets, recommended controls, and protocols.

• Translational Value: Applicable to biomarker research, therapeutic development, and clinical pipelines.

By selecting NSJ Bioreagents, researchers can rely on the Angiotensin I Converting Enzyme 2 Antibody for reliable and consistent detection of ACE2 in both fundamental and translational settings.

Applications of Angiotensin I Converting Enzyme 2 Antibodies

The Angiotensin I Converting Enzyme 2 Antibody supports a wide range of applications in cardiovascular biology, nephrology, virology, and translational research.

1) Cardiovascular Biology and Hypertension

• Detect ACE2 expression in cardiac tissue and vascular endothelium.

• Support studies of angiotensin-(1–7) generation and vasodilation.

• Validate biomarkers for hypertension, heart failure, and vascular remodeling.

• Extend applications into translational cardiology and therapeutic pipelines.

2) Renal Physiology and Fluid Balance

• Angiotensin I Converting Enzyme 2 Antibody detects expression in renal proximal tubules.

• Supports studies of sodium and water homeostasis.

• Provides biomarkers for diabetic nephropathy and chronic kidney disease.

• Extends into translational nephrology and personalized medicine.

3) Pulmonary Biology

• Detect ACE2 expression in alveolar epithelial cells.

• Support research into pulmonary hypertension and acute respiratory distress.

• Clarify ACE2’s protective role in lung injury and inflammation.

• Provide translational biomarkers for respiratory clinical research.

4) Infectious Disease and Virology

• Angiotensin I Converting Enzyme 2 Antibody supports detection of ACE2 in viral entry studies.

• Validates biomarkers for SARS-CoV-2 infection and COVID-19 pathogenesis.

• Clarifies tissue-specific susceptibility to viral binding.

• Provides translational markers for vaccine and antiviral development.

• Extends into comparative virology for coronaviruses and other pathogens.

5) Inflammation and Immunology

• Detect altered ACE2 expression during systemic inflammation.

• Support studies linking ACE2 to cytokine balance.

• Clarify how ACE2’s anti-inflammatory effects protect against fibrosis.

• Provide translational biomarkers for autoimmune disease pipelines.

6) Gastrointestinal and Metabolic Biology

• Angiotensin I Converting Enzyme 2 Antibody detects intestinal epithelial expression.

• Supports research into nutrient absorption and gut barrier integrity.

• Links ACE2 to metabolic diseases such as diabetes and obesity.

• Extends into translational gastroenterology and endocrinology.

7) Neurology and Brain Research

• Detect ACE2 expression in brain endothelial and neuronal populations.

• Support studies of cerebrovascular regulation and neuroprotection.

• Clarify potential roles for ACE2 in dementia and stroke recovery.

• Provide translational biomarkers for neurovascular disease research.

8) Pharmacology and Drug Discovery

• Angiotensin I Converting Enzyme 2 Antibody validates ACE2 as a therapeutic target.

• Supports research into ACE2 activators, inhibitors, and recombinant ACE2 therapies.

• Provides translational biomarkers for evaluating drug efficacy.

• Extends into antiviral drug pipelines targeting SARS-CoV-2.

9) Clinical and Diagnostic Research

• Detect ACE2 expression in human biopsies and patient samples.

• Support diagnostic development for cardiovascular and infectious disease.

• Provide biomarkers for COVID-19 severity and patient stratification.

• Ensure reproducibility in translational and clinical pipelines.

Why Are Angiotensin I Converting Enzyme 2 Antibodies Important?

ACE2 plays a dual role in physiology and disease: as a protective regulator in the renin–angiotensin system and as the entry receptor for SARS-CoV-2. The Angiotensin I Converting Enzyme 2 Antibody equips researchers with validated tools to investigate these roles across multiple tissues and disease contexts.

In cardiology, ACE2 detection clarifies its role in counterbalancing ACE activity and preventing maladaptive remodeling. In nephrology, it supports studies of kidney health and chronic disease. In pulmonary biology, it highlights ACE2’s protective function against lung injury. In virology, it remains central to COVID-19 research and antiviral development.

Clinically, ACE2 expression is now considered both a biomarker and therapeutic target. Reliable ACE2 Antibody reagents ensure reproducibility, enabling scientists to bridge basic biology with diagnostics, drug development, and personalized medicine.

Conclusion

ACE2 is a unique enzyme with roles in vascular regulation, renal physiology, pulmonary health, and viral pathogenesis. The Angiotensin I Converting Enzyme 2 Antibody provides validated tools for cardiovascular and infectious disease research, while the ACE2 Antibody complements this work across translational and clinical pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing cardiovascular and viral biology, as well as improving clinical outcomes.