Cyclooxygenase 2 Antibody / COX2 Antibody

Cyclooxygenase 2 Antibody Overview

Cyclooxygenase 2 Antibody reagents target COX2 (also known as PTGS2), an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, lipid mediators central to inflammation and tissue homeostasis. Unlike COX1, which is constitutively expressed, COX2 is inducible and rapidly upregulated by cytokines, growth factors, and stress signals. This makes COX2 a critical mediator of inflammatory responses, angiogenesis, and tumor progression.

COX2 is overexpressed in numerous cancers, including colorectal, breast, lung, and prostate malignancies, where it promotes tumor growth, angiogenesis, and resistance to apoptosis. It also plays major roles in inflammatory diseases such as arthritis, cardiovascular disease, and neurodegeneration. Because of its wide biological significance, the Cyclooxygenase 2 Antibody is an essential tool for immunology, oncology, and translational research. The COX2 Antibody further supports clinical pathology and drug development studies focused on prostaglandin biology and COX2 inhibition.

Why Choose Cyclooxygenase 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Cyclooxygenase 2 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, and ELISA. Each Cyclooxygenase 2 Antibody undergoes rigorous quality testing to ensure specificity, sensitivity, and reproducibility.

By selecting Cyclooxygenase 2 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and consistency. Our antibodies provide strong detection of COX2 in tissues and cell lines, reproducible protein quantification, and reliable performance across experimental platforms. Comprehensive datasheets, recommended positive controls, and validated protocols further support reproducibility in both research and clinical applications.

Applications of Cyclooxygenase 2 Antibodies

The Cyclooxygenase 2 Antibody supports a broad spectrum of research and clinical uses.

1) Inflammation and Immunology

• Cyclooxygenase 2 Antibodies detect inducible COX2 expression in immune cells.

• The Cyclooxygenase 2 Antibody supports studies of cytokine-driven inflammatory pathways.

• COX2 Antibody reagents clarify prostaglandin-mediated signaling in chronic inflammation.

2) Oncology and Tumor Biology

• Cyclooxygenase 2 Antibodies highlight COX2 overexpression in colorectal and breast cancers.

• The Cyclooxygenase 2 Antibody supports biomarker discovery for tumor angiogenesis.

• COX2 Antibody reagents contribute to translational oncology research.

3) Cardiovascular Research

• Cyclooxygenase 2 Antibodies monitor COX2 activity in vascular endothelial cells.

• The Cyclooxygenase 2 Antibody supports studies into prostaglandin roles in atherosclerosis.

• COX2 Antibody reagents validate biomarkers for cardiovascular disease progression.

4) Neuroscience and Neurodegeneration

• Cyclooxygenase 2 Antibodies detect COX2 in neurons and glial cells.

• The Cyclooxygenase 2 Antibody supports research into neuroinflammation in Alzheimer’s and Parkinson’s disease.

• COX2 Antibody reagents contribute to understanding prostaglandin signaling in the brain.

5) Drug Discovery and Pharmacology

• Cyclooxygenase 2 Antibodies help evaluate the efficacy of COX2 inhibitors such as NSAIDs and coxibs.

• The Cyclooxygenase 2 Antibody validates pharmacodynamic biomarkers in preclinical models.

• COX2 Antibody reagents support translational pipelines for anti-inflammatory therapies.

6) Translational and Clinical Research

• Cyclooxygenase 2 Antibodies are validated in biomarker-driven clinical trials.

• The Cyclooxygenase 2 Antibody supports patient stratification in oncology and inflammatory disease.

• COX2 Antibody reagents provide reproducibility across research and diagnostics.

Why Are Cyclooxygenase 2 Antibodies Important?

COX2 is a central enzyme linking inflammation, tissue repair, and cancer progression. The Cyclooxygenase 2 Antibody equips researchers with validated tools to detect and study this enzyme, while the COX2 Antibody extends applications into diagnostics, drug development, and translational medicine.

In immunology, Cyclooxygenase 2 Antibodies reveal cytokine-induced inflammatory responses. In oncology, the Cyclooxygenase 2 Antibody highlights tumor angiogenesis and immune evasion. In cardiovascular and neuroscience research, COX2 Antibody reagents clarify the role of prostaglandins in disease pathology.

Clinically, COX2 expression and inhibition remain central to anti-inflammatory and cancer therapies. Cyclooxygenase 2 Antibodies ensure reproducibility, reliability, and translational value, bridging laboratory research with clinical application.

Conclusion

Cyclooxygenase 2 is a pivotal inducible enzyme with essential roles in inflammation, cancer, and tissue homeostasis. The Cyclooxygenase 2 Antibody provides researchers and clinicians with validated reagents for detecting COX2 across biology, pathology, and pharmacology, while the COX2 Antibody supports broader applications in translational research and therapy development. By ensuring specificity and reproducibility, these antibodies remain indispensable tools for advancing biomedical research and improving patient outcomes.