COX-2 Antibody / Cyclooxygenase-2 Antibody

COX-2 Antibody Overview

COX-2 Antibody reagents target cyclooxygenase-2 (PTGS2), an inducible enzyme that regulates the biosynthesis of prostaglandins from arachidonic acid. Unlike COX-1, which maintains basal physiological functions, COX-2 is rapidly upregulated in response to cytokines, mitogens, and environmental stress. This inducible nature makes COX-2 a central mediator of inflammation, tissue repair, angiogenesis, and cancer progression.

COX-2 overexpression has been documented in many cancers, including colorectal, lung, breast, and prostate tumors. It enhances proliferation, promotes angiogenesis, and suppresses apoptosis, linking prostaglandin biology with oncogenesis. Elevated COX-2 is also observed in inflammatory diseases such as arthritis, asthma, and atherosclerosis, highlighting its importance across multiple organ systems. Because of these diverse roles, the COX-2 Antibody is indispensable for research in oncology, immunology, and pharmacology, while the Cyclooxygenase-2 Antibody further supports translational medicine and clinical diagnostics.

Why Choose COX-2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents supplies COX-2 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, and ELISA. Each COX-2 Antibody is carefully tested to ensure high specificity, minimal cross-reactivity, and reproducibility across applications.

By choosing COX-2 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and consistency. Our antibodies provide robust detection of COX-2 in tissue samples and cell lines, reproducible protein quantification, and reliable performance across experimental workflows. Comprehensive datasheets, validated controls, and optimized protocols further support reproducibility in research and diagnostic settings.

Applications of COX-2 Antibodies

The COX-2 Antibody supports broad and impactful research across inflammation, cancer, and therapeutic development.

1) Inflammatory Pathways

• COX-2 Antibodies detect inducible enzyme expression in activated immune cells.

• The COX-2 Antibody supports studies of prostaglandin-driven inflammation.

• Cyclooxygenase-2 Antibody reagents highlight chronic inflammatory processes in arthritis and asthma.

2) Oncology and Tumor Biology

• COX-2 Antibodies identify overexpression in colorectal, breast, and lung carcinomas.

• The COX-2 Antibody supports biomarker discovery in angiogenesis and metastasis.

• Cyclooxygenase-2 Antibody reagents validate tumor biology studies in translational oncology.

3) Cardiovascular Research

• COX-2 Antibodies highlight endothelial and smooth muscle cell activation.

• The COX-2 Antibody supports studies into atherosclerosis and vascular remodeling.

• Cyclooxygenase-2 Antibody reagents provide insight into prostaglandin-mediated vascular function.

4) Neuroscience and Neuroinflammation

• COX-2 Antibodies detect expression in neurons and glial cells.

• The COX-2 Antibody supports studies of neuroinflammation in Alzheimer’s and Parkinson’s disease.

• Cyclooxygenase-2 Antibody reagents help clarify prostaglandin roles in brain pathology.

5) Drug Discovery and Pharmacology

• COX-2 Antibodies are used to evaluate inhibitors, including NSAIDs and coxibs.

• The COX-2 Antibody validates pharmacological targets in preclinical models.

• Cyclooxygenase-2 Antibody reagents provide biomarker tools for anti-inflammatory drug development.

6) Translational and Clinical Research

• COX-2 Antibodies are applied in biomarker-driven clinical trials.

• The COX-2 Antibody supports patient monitoring in cancer and inflammatory disease.

• Cyclooxygenase-2 Antibody reagents ensure reproducibility across translational medicine.

Why Are COX-2 Antibodies Important?

COX-2 is a pivotal enzyme bridging inflammation, prostaglandin signaling, and cancer progression. The COX-2 Antibody provides precise detection of inducible COX-2 expression, while the Cyclooxygenase-2 Antibody extends its use to pathology, diagnostics, and clinical applications.

In inflammation research, COX-2 Antibodies clarify cytokine-induced signaling pathways. In oncology, the COX-2 Antibody highlights tumor angiogenesis and metastasis. In cardiovascular and neuroscience studies, Cyclooxygenase-2 Antibody reagents help explain vascular and neurological prostaglandin roles.

Clinically, COX-2 expression and inhibition remain central to drug development, particularly in anti-inflammatory and cancer therapies. COX-2 Antibodies ensure reproducibility, reliability, and translational impact, bridging laboratory science with patient care.

Conclusion

COX-2 is an inducible cyclooxygenase enzyme with vital roles in inflammation, cancer, and tissue homeostasis. The COX-2 Antibody equips researchers and clinicians with validated reagents for detecting this enzyme across immunology, oncology, and pharmacology, while the Cyclooxygenase-2 Antibody provides broader applications in diagnostics and translational medicine. By ensuring specificity and reproducibility, these antibodies remain indispensable tools for advancing biomedical science and improving clinical outcomes.