Aquaporin 4 Antibody / AQP4 Antibody

Aquaporin 4 Antibody Overview

Aquaporin 4 Antibody reagents target AQP4, a key water channel highly expressed in astrocytic end-feet at the blood–brain barrier and ependymal cells lining the ventricles. AQP4 regulates bidirectional water movement between blood and brain, playing a critical role in cerebral water balance, edema, and neural function. It is also a central molecule in neuroinflammation, where altered expression contributes to multiple neurological diseases.

Dysregulated AQP4 is linked to neuromyelitis optica (NMO), epilepsy, traumatic brain injury, stroke, and Alzheimer’s disease. Because of its critical role in CNS fluid balance and pathology, the Aquaporin 4 Antibody is an essential reagent for neuroscience, neuropathology, and translational medicine. The AQP4 Antibody collection complements these studies with validated reagents for multiple assays and comparative research.

Why Choose Aquaporin 4 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Aquaporin 4 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, ELISA, and flow cytometry. Each Aquaporin 4 Antibody undergoes rigorous validation to ensure specificity, reproducibility, and robust performance across neuroscience workflows.

By choosing Aquaporin 4 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and consistency. Our antibodies deliver strong staining in brain tissue, reproducible detection in lysates, and dependable performance in translational studies. Comprehensive datasheets, validated controls, and optimized protocols support reproducibility across laboratory and clinical applications.

Applications of Aquaporin 4 Antibodies

The Aquaporin 4 Antibody supports diverse applications in CNS biology, pathology, and clinical research.

1) Neuroscience and Brain Function

• Aquaporin 4 Antibodies detect expression in astrocytes at the blood–brain barrier.

• The Aquaporin 4 Antibody supports studies of cerebral water homeostasis.

• AQP4 Antibody reagents clarify astrocytic regulation of ion and neurotransmitter balance.

2) Neuroinflammation and Autoimmune Disorders

• Aquaporin 4 Antibodies identify AQP4 as the main target in neuromyelitis optica (NMO).

• The Aquaporin 4 Antibody supports research into autoimmune demyelination.

• AQP4 Antibody reagents validate biomarkers for NMO diagnosis and therapy.

3) Stroke and Traumatic Brain Injury

• Aquaporin 4 Antibodies highlight altered expression after ischemia and trauma.

• The Aquaporin 4 Antibody supports studies of brain edema and recovery.

• AQP4 Antibody reagents contribute to translational neuroprotection research.

4) Epilepsy and Neural Excitability

• Aquaporin 4 Antibodies reveal roles in potassium buffering and synaptic activity.

• The Aquaporin 4 Antibody supports studies of seizure susceptibility.

• AQP4 Antibody reagents provide biomarkers for excitability-related disorders.

5) Neurodegenerative Diseases

• Aquaporin 4 Antibodies detect altered expression in Alzheimer’s and Parkinson’s disease.

• The Aquaporin 4 Antibody supports studies of glymphatic clearance of amyloid.

• AQP4 Antibody reagents extend applications into neurodegeneration research.

6) Translational and Clinical Research

• Aquaporin 4 Antibodies are applied in biomarker-driven neurological studies.

• The Aquaporin 4 Antibody supports patient stratification and therapy monitoring.

• AQP4 Antibody reagents ensure reproducibility in translational pipelines.

Why Are Aquaporin 4 Antibodies Important?

AQP4 is the principal water channel in the CNS, central to astrocytic function and blood–brain barrier physiology. The Aquaporin 4 Antibody provides validated tools for studying water balance, neuroinflammation, and brain pathology, while the AQP4 Antibody extends applications across translational research.

In neuroscience, Aquaporin 4 Antibodies clarify astrocytic contributions to synaptic regulation and water transport. In neuroinflammation, the Aquaporin 4 Antibody provides insights into NMO and related disorders. In neurodegeneration, AQP4 Antibody reagents highlight its role in waste clearance and pathology progression.

Clinically, AQP4 is both a biomarker and therapeutic target, particularly in NMO where autoantibodies against AQP4 drive disease. Reliable Aquaporin 4 Antibodies ensure reproducibility, bridging basic neuroscience with diagnostic and clinical applications.

Conclusion

AQP4 is a critical aquaporin that regulates CNS water balance and contributes to multiple neurological disorders. The Aquaporin 4 Antibody provides validated reagents for studying astrocytes, blood–brain barrier physiology, and neuroinflammation, while the AQP4 Antibody expands these applications across translational and clinical research. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing neuroscience and improving patient outcomes.