Aquaporin 11 Antibody / AQP11 Antibody

Aquaporin 11 Antibody Overview

Aquaporin 11 Antibody reagents target AQP11, an unconventional aquaporin distinguished by its low sequence homology with classical family members and atypical permeability properties. Unlike traditional aquaporins that primarily facilitate water transport, AQP11 localizes to the endoplasmic reticulum (ER) and participates in intracellular fluid balance and organelle homeostasis.

AQP11 is expressed in the kidney, particularly in proximal tubules, where it regulates intracellular water flux and ER function. Genetic studies have shown that disruption of AQP11 leads to polycystic kidney-like phenotypes, highlighting its importance in renal physiology and disease. AQP11 is also expressed in testis, liver, and brain, suggesting broader roles in development, metabolism, and stress responses. Because of its unique biology, the Aquaporin 11 Antibody is a valuable tool for studying ER-associated pathways, renal physiology, and translational disease models. The AQP11 Antibody category provides complementary reagents for diverse experimental applications.

Why Choose Aquaporin 11 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Aquaporin 11 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and ELISA. Each Aquaporin 11 Antibody undergoes rigorous testing to ensure specificity, reproducibility, and performance across multiple assay systems.

By choosing Aquaporin 11 Antibodies from NSJ Bioreagents, scientists gain reagents optimized for clarity and consistency. Our antibodies provide strong staining in kidney tissues, reproducible detection in protein lysates, and dependable results across translational workflows. Detailed datasheets, recommended controls, and optimized protocols support reproducibility in both laboratory and clinical pipelines.

Applications of Aquaporin 11 Antibodies

The Aquaporin 11 Antibody supports wide-ranging applications in nephrology, ER biology, and translational medicine.

1) Kidney and Renal Physiology

• Aquaporin 11 Antibodies detect AQP11 in proximal tubules.

• The Aquaporin 11 Antibody supports studies of renal water handling and solute balance.

• AQP11 Antibody reagents validate biomarkers for kidney development and disease.

2) Endoplasmic Reticulum and Stress Biology

• Aquaporin 11 Antibodies highlight ER localization and fluid regulation.

• The Aquaporin 11 Antibody supports studies of ER stress and unfolded protein response.

• AQP11 Antibody reagents clarify links to apoptosis and autophagy.

3) Polycystic Kidney Disease and Renal Pathology

• Aquaporin 11 Antibodies identify altered expression in cystic kidney phenotypes.

• The Aquaporin 11 Antibody supports studies of genetic and acquired renal disorders.

• AQP11 Antibody reagents provide translational tools for nephrology.

4) Developmental and Reproductive Biology

• Aquaporin 11 Antibodies detect expression in testis and embryonic tissues.

• The Aquaporin 11 Antibody supports studies of fertility and developmental physiology.

• AQP11 Antibody reagents extend applications to organogenesis.

5) Neuroscience and Brain Biology

• Aquaporin 11 Antibodies reveal expression in select brain regions.

• The Aquaporin 11 Antibody supports studies of water balance and ER function in neurons.

• AQP11 Antibody reagents provide biomarkers for neurodegeneration research.

6) Translational and Clinical Research

• Aquaporin 11 Antibodies are integrated into biomarker-driven nephrology studies.

• The Aquaporin 11 Antibody supports diagnostics for kidney and metabolic disorders.

• AQP11 Antibody reagents ensure reproducibility in translational pipelines.

Why Are Aquaporin 11 Antibodies Important?

AQP11 represents a noncanonical aquaporin with unique roles in organelle homeostasis and renal physiology. The Aquaporin 11 Antibody equips researchers with validated reagents for studying ER biology, stress responses, and kidney disease, while the AQP11 Antibody supports translational and diagnostic applications.

In renal research, Aquaporin 11 Antibodies highlight roles in proximal tubule physiology and cystic kidney disease. In ER biology, the Aquaporin 11 Antibody clarifies mechanisms of protein folding and stress regulation. In translational studies, AQP11 Antibody reagents validate biomarkers for renal and metabolic disorders.

Clinically, AQP11 is emerging as a biomarker for kidney disease and ER-related pathologies. Reliable Aquaporin 11 Antibodies ensure reproducibility, bridging fundamental research with translational and clinical outcomes.

Conclusion

AQP11 is a unique aquaporin that localizes to the endoplasmic reticulum and contributes to kidney physiology, ER stress regulation, and systemic health. The Aquaporin 11 Antibody provides validated reagents for nephrology, ER biology, and developmental research, while the AQP11 Antibody extends applications into translational and diagnostic pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing aquaporin research and improving clinical outcomes.