AQP11 Antibody / Aquaporin 11 Antibody

AQP11 Antibody Overview

AQP11 Antibody reagents target aquaporin 11, an unconventional aquaporin with atypical sequence motifs and unique intracellular localization. Unlike canonical aquaporins at the plasma membrane, AQP11 resides primarily in the endoplasmic reticulum, where it regulates water and small solute balance in organelles. Its role extends to ER stress, protein folding, and organelle homeostasis, making AQP11 essential for cell survival under metabolic or oxidative challenge.

AQP11 expression is highest in the kidney proximal tubules, but it is also found in testis, liver, and brain. Genetic disruption of AQP11 in mouse models leads to cystic kidney phenotypes, highlighting its importance in nephrology. Dysregulated expression may also link AQP11 to metabolic syndrome, infertility, and neurodegeneration. Because of these diverse and unique roles, the AQP11 Antibody is an indispensable reagent for ER biology, kidney physiology, and translational research. The Aquaporin 11 Antibody extends these applications with validated compatibility across multiple assays.

Why Choose AQP11 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides AQP11 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and ELISA. Each AQP11 Antibody undergoes rigorous validation for specificity, reproducibility, and assay versatility.

By choosing AQP11 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for reliability and clarity. Our antibodies produce robust detection in kidney tissue, strong ER-localized signals, and reproducible results in lysate and clinical studies. Detailed datasheets, suggested controls, and optimized protocols ensure reproducibility across diverse research environments.

Applications of AQP11 Antibodies

The AQP11 Antibody supports wide-ranging applications in organelle biology, kidney disease, and translational medicine.

1) Endoplasmic Reticulum Stress and Biology

• AQP11 Antibodies clarify roles in ER homeostasis and protein folding.

• The AQP11 Antibody supports studies of unfolded protein response and apoptosis.

• Aquaporin 11 Antibody reagents contribute to translational stress biology.

2) Kidney and Nephrology Research

• AQP11 Antibodies detect expression in proximal tubules.

• The AQP11 Antibody supports studies of cystic kidney disorders and renal physiology.

• Aquaporin 11 Antibody reagents validate nephrology biomarkers.

3) Genetic Models and Developmental Biology

• AQP11 Antibodies highlight phenotypes in knockout models.

• The AQP11 Antibody supports studies of kidney development and organogenesis.

• Aquaporin 11 Antibody reagents clarify genetic regulation of aquaporins.

4) Metabolism and Energy Regulation

• AQP11 Antibodies reveal roles in liver and testis related to metabolic balance.

• The AQP11 Antibody supports studies of lipid and glucose regulation.

• Aquaporin 11 Antibody reagents extend applications to metabolic syndrome research.

5) Neuroscience and Brain Research

• AQP11 Antibodies detect expression in select neuronal populations.

• The AQP11 Antibody supports research into ER stress and neurodegeneration.

• Aquaporin 11 Antibody reagents provide translational insights into brain pathology.

6) Translational and Clinical Research

• AQP11 Antibodies are applied in biomarker-driven nephrology and metabolic studies.

• The AQP11 Antibody supports diagnostics for renal cystic disease.

• Aquaporin 11 Antibody reagents ensure reproducibility in translational pipelines.

Why Are AQP11 Antibodies Important?

AQP11 stands apart from other aquaporins due to its localization in the endoplasmic reticulum and its unique permeability properties. The AQP11 Antibody equips scientists with validated reagents for exploring ER stress, cystic kidney disease, and metabolic disorders, while the Aquaporin 11 Antibody expands these applications into translational and clinical settings.

In ER biology, AQP11 Antibodies clarify how organelle water regulation influences protein folding and survival. In nephrology, the AQP11 Antibody supports studies of cystic phenotypes and renal development. In metabolic research, Aquaporin 11 Antibody reagents extend applications into energy balance and infertility.

Clinically, AQP11 is being investigated as a biomarker for kidney disease, metabolic dysfunction, and ER stress–related pathologies. Reliable AQP11 Antibodies ensure reproducibility, bridging basic discoveries with translational and diagnostic pipelines.

Conclusion

AQP11 is a noncanonical aquaporin that functions in the endoplasmic reticulum, regulating water and solute balance in organelles and contributing to systemic physiology. The AQP11 Antibody provides validated reagents for ER biology, nephrology, and metabolic research, while the Aquaporin 11 Antibody extends applications into translational and clinical pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing aquaporin research and improving clinical outcomes.