AQP2 Antibody / Aquaporin 2 Antibody

AQP2 Antibody Overview

AQP2 Antibody reagents target aquaporin 2, a vasopressin-regulated water channel crucial for systemic water balance. AQP2 is expressed in principal cells of the renal collecting duct, where its trafficking to the apical membrane determines how much water is reabsorbed into the bloodstream. This hormone-controlled localization makes AQP2 a central player in kidney physiology and endocrine regulation.

Defective AQP2 regulation contributes to nephrogenic diabetes insipidus, characterized by excessive urination and dehydration, as well as other disorders of water homeostasis. AQP2 expression levels and membrane trafficking are also influenced by pharmacological agents, highlighting its importance in drug discovery. Because of its tight link to vasopressin signaling and hydration disorders, the AQP2 Antibody is indispensable for nephrology, endocrinology, and pharmacology research. The Aquaporin 2 Antibody provides validated detection across multiple experimental systems, ensuring reproducibility in both basic and clinical studies.

Why Choose AQP2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides AQP2 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and ELISA. Each AQP2 Antibody undergoes rigorous validation for specificity, reproducibility, and assay compatibility.

By choosing AQP2 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and reliability. Our antibodies consistently provide strong staining in renal collecting ducts, reproducible results in lysates, and dependable performance across translational pipelines. Comprehensive datasheets, suggested controls, and optimized protocols support reproducibility in both laboratory and clinical contexts.

Applications of AQP2 Antibodies

The AQP2 Antibody supports broad applications in kidney research, endocrinology, and pharmacology.

1) Vasopressin and Endocrine Regulation

• AQP2 Antibodies detect vasopressin-regulated trafficking in collecting duct cells.

• The AQP2 Antibody supports studies of hormone-driven water reabsorption.

• Aquaporin 2 Antibody reagents validate biomarkers for endocrine physiology.

2) Diabetes Insipidus Research

• AQP2 Antibodies reveal expression changes in nephrogenic and central diabetes insipidus.

• The AQP2 Antibody supports therapeutic development for hydration disorders.

• Aquaporin 2 Antibody reagents provide translational biomarkers for diagnostics.

3) Pharmacology and Drug Discovery

• AQP2 Antibodies are used to test vasopressin analogs and receptor modulators.

• The AQP2 Antibody supports pharmacodynamic studies of water balance therapies.

• Aquaporin 2 Antibody reagents ensure reproducibility in preclinical trials.

4) Kidney and Renal Physiology

• AQP2 Antibodies highlight expression in renal collecting ducts.

• The AQP2 Antibody supports studies of systemic water handling.

• Aquaporin 2 Antibody reagents provide markers for nephrology research.

5) Developmental and Comparative Biology

• AQP2 Antibodies detect expression across developmental stages.

• The AQP2 Antibody supports studies of kidney maturation and endocrine control.

• Aquaporin 2 Antibody reagents extend research into aquaporin evolution.

6) Translational and Clinical Research

• AQP2 Antibodies are integrated into biomarker-driven nephrology and endocrinology pipelines.

• The AQP2 Antibody supports diagnostics for water balance disorders.

• Aquaporin 2 Antibody reagents ensure reproducibility in clinical applications.

Why Are AQP2 Antibodies Important?

AQP2 is unique among aquaporins because its activity is dynamically regulated by hormones rather than being constitutively expressed at the plasma membrane. The AQP2 Antibody equips scientists with validated tools for studying endocrine control of water balance, while the Aquaporin 2 Antibody expands applications into translational and pharmacological research.

In endocrinology, AQP2 Antibodies highlight vasopressin-regulated trafficking mechanisms. In pharmacology, the AQP2 Antibody supports drug development targeting vasopressin receptors and downstream pathways. In nephrology, Aquaporin 2 Antibody reagents clarify mechanisms of water balance disorders such as diabetes insipidus.

Clinically, AQP2 is a biomarker for hydration status and a therapeutic target in water balance disorders. Reliable AQP2 Antibodies ensure reproducibility, bridging endocrine research with diagnostic and clinical applications.

Conclusion

AQP2 is a vasopressin-regulated water channel at the heart of systemic hydration and kidney function. The AQP2 Antibody provides validated reagents for studying endocrine regulation, pharmacological interventions, and renal physiology, while the Aquaporin 2 Antibody extends applications across translational and diagnostic pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing kidney, endocrine, and pharmacology research.