NSJ Bioreagents

Actin Antibody Overview

Actin Antibody reagents target actin, one of the most abundant and highly conserved proteins in eukaryotic cells. Actin forms the core of the cytoskeleton, where it provides mechanical support, organizes cell shape, drives motility, and mediates intracellular transport. It polymerizes into filaments (F-actin) and dynamically transitions between monomeric (G-actin) and filamentous states, enabling rapid cellular responses to environmental signals.

Actin is expressed ubiquitously, but its regulation is highly specialized in different tissues. Muscle cells use actin filaments for contraction, while non-muscle cells rely on actin for migration, endocytosis, cytokinesis, and intracellular trafficking. Actin also plays regulatory roles in gene expression, signal transduction, and host–pathogen interactions.

Because of these central roles, the Actin Antibody is indispensable for cell biology, developmental biology, neuroscience, cancer research, and translational pipelines. The broader Actin Antibodies portfolio supports reliable detection of multiple isoforms across applications.

Why Choose Actin Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Actin Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous testing to ensure specificity, reproducibility, and cross-platform reliability.

Benefits include:

Ubiquitous Target: Detection across muscle and non-muscle tissues.
Versatility: Compatible with multiple assay systems.
Reproducibility: Consistent results across batches.
Comprehensive Support: Detailed datasheets with suggested controls and protocols.
Translational Value: Suitable for biomarker research and clinical pipelines.

By selecting NSJ Bioreagents, researchers can depend on the Actin Antibody for robust detection of this essential cytoskeletal protein.

Applications of Actin Antibodies

The Actin Antibody supports broad applications across biology, medicine, and translational research.

1) Cytoskeleton and Cell Structure

Detect actin filaments in fixed or live cells.
Support studies of cytoskeletal dynamics and remodeling.
Clarify roles in maintaining cell polarity and architecture.
Provide biomarkers for cytoskeletal regulation in health and disease.

2) Cell Migration and Motility

Actin Antibody detects lamellipodia and filopodia structures.
Supports studies of cancer metastasis and immune cell migration.
Provides biomarkers for wound healing and tissue repair.
Extends into translational pipelines targeting cell motility.

3) Muscle Biology and Contraction

Detect actin isoforms in skeletal, cardiac, and smooth muscle.
Support studies of sarcomere assembly and contractile function.
Provide biomarkers for inherited myopathies and cardiomyopathies.
Extend into regenerative medicine and stem cell differentiation.

4) Developmental Biology

Actin Antibody detects dynamic remodeling during embryogenesis.
Supports studies of morphogenesis, organ development, and cell fate.
Provides biomarkers for cytoskeletal regulation in development.
Extends into regenerative biology and tissue engineering.

5) Cancer and Tumor Biology

Detect altered actin organization in invasive cancer cells.
Support studies of actin-binding proteins in tumor progression.
Provide biomarkers for metastasis and therapeutic response.
Extend into translational oncology pipelines.

6) Neuroscience and Synaptic Biology

Actin Antibody detects synaptic actin in dendritic spines.
Supports studies of plasticity, learning, and memory.
Provides biomarkers for actin dysregulation in neurodegeneration.
Extends into translational neuroscience research.

7) Immunology and Host Defense

Detect actin remodeling during immune cell activation.
Support studies of phagocytosis and antigen presentation.
Provide biomarkers for immune cell migration and pathogen defense.
Extend into translational immunology pipelines.

8) Translational and Clinical Research

Actin Antibody provides reproducible markers for disease diagnostics.
Supports clinical studies of cytoskeletal alterations in cancer, neurodegeneration, and immune disorders.
Ensures reliability in biomarker-driven pipelines.
Bridges basic cytoskeletal biology with clinical translation.

Why Are Actin Antibodies Important?

Actin is fundamental to nearly every cellular process. The Actin Antibody provides researchers with validated tools for detecting actin in muscle contraction, migration, immune defense, and signaling.

In cell biology, it clarifies cytoskeletal organization and remodeling. In oncology, it highlights actin’s role in metastasis and invasion. In neuroscience, it reveals synaptic actin remodeling in plasticity and degeneration. In immunology, it supports studies of pathogen defense and immune activation.

Clinically, actin is used as a biomarker for sample loading in western blotting (housekeeping protein) and for pathology in muscle and cancer biopsies. Reliable Actin Antibodies ensure reproducibility across discovery, translational, and clinical research pipelines.

Conclusion

Actin is a universal cytoskeletal protein central to cellular structure, motility, and signaling. The Actin Antibody provides validated tools for cell biology, cancer, neuroscience, and clinical research, while Actin Antibodies support diverse applications across isoforms and tissues. By ensuring specificity, reproducibility, and versatility, these antibodies remain indispensable for advancing basic biology and translational medicine.