Acetyl-CoA acetyltransferase Antibody / ACAT1 Antibody

Acetyl-CoA Acetyltransferase Antibody Overview

Acetyl-CoA Acetyltransferase Antibody reagents target ACAT1, a mitochondrial enzyme central to ketone body metabolism, cholesterol balance, and cellular energy regulation. Also known as thiolase, ACAT1 catalyzes the reversible condensation of two acetyl-CoA molecules to form acetoacetyl-CoA, an essential step in ketogenesis, fatty acid oxidation, and cholesterol metabolism.

ACAT1 is widely expressed in metabolic tissues, including liver, heart, muscle, and kidney. Its regulation influences energy supply during fasting, exercise, and nutrient deprivation. Beyond metabolism, ACAT1 is implicated in cancer metabolism, neurodegeneration, and rare inherited metabolic disorders.

Mutations in ACAT1 cause beta-ketothiolase deficiency, a rare autosomal recessive disorder characterized by episodes of ketoacidosis, metabolic imbalance, and neurologic symptoms. Because of its critical roles in health and disease, the Acetyl-CoA Acetyltransferase Antibody is indispensable for research into energy homeostasis, inborn errors of metabolism, and translational medicine. The ACAT1 Antibody provides reproducible detection across multiple experimental platforms.

Why Choose Acetyl-CoA Acetyltransferase Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Acetyl-CoA Acetyltransferase Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous validation for specificity, reproducibility, and assay performance.

Key benefits include:

• Metabolic Relevance: Targets a core enzyme in ketone body and cholesterol pathways.

• Assay Versatility: Validated across diverse biological models.

• Reproducibility: Ensures batch-to-batch consistency.

• Comprehensive Data: Datasheets with controls and recommended protocols.

• Translational Utility: Suitable for biomarker-driven and clinical research.

With NSJ Bioreagents, scientists can rely on the Acetyl-CoA Acetyltransferase Antibody for accuracy and reproducibility across metabolic and translational research.

Applications of Acetyl-CoA Acetyltransferase Antibodies

The Acetyl-CoA Acetyltransferase Antibody supports wide-ranging applications in energy metabolism, inherited disorders, oncology, and translational biology.

1) Ketogenesis and Energy Balance

• Detect ACAT1 expression in liver and metabolic tissues.

• Support studies of ketone body production during fasting or exercise.

• Provide biomarkers for ketogenic diet research.

• Extend into translational pipelines for metabolic disease.

2) Fatty Acid and Lipid Metabolism

• Acetyl-CoA Acetyltransferase Antibody detects enzyme activity in fatty acid oxidation.

• Supports studies of acetyl-CoA flux and lipid utilization.

• Provides biomarkers for lipid metabolism disorders.

• Extends into pharmacology pipelines for metabolic interventions.

3) Cholesterol and Steroid Biosynthesis

• Detect ACAT1’s role in cholesterol balance.

• Support studies of steroid hormone precursor regulation.

• Provide biomarkers for dyslipidemia and cardiovascular risk.

• Extend into translational cardiovascular research.

4) Inherited Metabolic Disorders

• Acetyl-CoA Acetyltransferase Antibody detects mutations causing beta-ketothiolase deficiency.

• Supports functional studies of enzyme deficiency in patient samples.

• Provides biomarkers for diagnostics and genetic counseling.

• Extends into translational rare disease research.

5) Cancer Metabolism

• Detect altered ACAT1 expression in tumor cells.

• Support studies of metabolic reprogramming in cancer.

• Provide biomarkers for therapeutic targeting of metabolic pathways.

• Extend into translational oncology pipelines.

6) Neurodegeneration and Brain Metabolism

• ACAT1 expression is linked to neuronal energy supply.

• Antibodies support research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

• Provide biomarkers for ketone metabolism in brain health.

• Extend into translational neuroscience.

7) Pharmacology and Drug Development

• ACAT1 is a therapeutic target for metabolic and oncologic interventions.

• Antibodies validate drug effects on ACAT1 expression.

• Provide translational biomarkers for efficacy testing.

• Extend into pharmaceutical research pipelines.

8) Translational and Clinical Research

• Acetyl-CoA Acetyltransferase Antibody supports biomarker-driven diagnostics.

• Provides reproducibility in clinical and translational pipelines.

• Links basic biology to therapeutic applications in metabolic disease.

• Ensures reliability across research, diagnostics, and clinical translation.

Why Are Acetyl-CoA Acetyltransferase Antibodies Important?

ACAT1 is a central enzyme at the intersection of ketogenesis, lipid metabolism, and cholesterol regulation. The Acetyl-CoA Acetyltransferase Antibody provides researchers with validated tools to investigate these roles in health and disease.

In metabolic biology, it clarifies mechanisms of energy balance during fasting and exercise. In clinical research, it supports studies of inborn errors such as beta-ketothiolase deficiency. In oncology, it highlights metabolic shifts that fuel tumor growth. In neuroscience, it reveals how ketone metabolism influences brain function and neurodegeneration.

Clinically, ACAT1 is both a biomarker and therapeutic target for inherited disease, cancer, and metabolic syndromes. Reliable ACAT1 Antibody reagents ensure reproducibility across laboratory discovery, translational studies, and clinical pipelines.

Conclusion

ACAT1 is a mitochondrial enzyme essential for ketogenesis, cholesterol regulation, and fatty acid metabolism. The Acetyl-CoA Acetyltransferase Antibody provides validated reagents for metabolic biology, inherited disorders, cancer, and translational research, while the ACAT1 Antibody complements these applications across multiple assays. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing metabolic and clinical research.