Recombinant Chromogranin A Antibody [clone CHGA/1731R] (V3824)

Description

Recombinant Chromogranin A antibody is a dependable tool for detecting chromogranin A, a secretory glycoprotein encoded by the CHGA gene and stored in dense core granules of neuroendocrine cells. Chromogranin A plays key roles in hormone storage, regulated secretion, and peptide hormone processing. Because of its broad distribution across endocrine tissues and tumors, chromogranin A is a central subject in neuroendocrine biology, pathology, and translational medicine.

Chromogranin A is cleaved into smaller peptides with biological activity, including vasostatin, pancreastatin, and catestatin. These fragments influence vascular tone, metabolic regulation, and neuroimmune interactions, highlighting the wide functional range of this protein. Its circulating levels are widely used as biomarkers for neuroendocrine tumors, providing diagnostic and prognostic value in cancers of the pancreas, adrenal glands, and gastrointestinal tract.

The Recombinant Chromogranin A antibody clone CHGA/1731R ensures reproducible and specific recognition. Recombinant production removes lot-to-lot variability, supporting consistency in long-term studies. Clone CHGA/1731R has been used in peer-reviewed publications investigating neuroendocrine tumor classification and endocrine peptide regulation, further demonstrating its utility in both research and diagnostic contexts.

Studies with clone CHGA/1731R have expanded understanding of how chromogranin A contributes to secretory granule biogenesis and regulated exocytosis. Elevated chromogranin A levels in plasma have been linked to neuroendocrine malignancies, pheochromocytomas, and paragangliomas, reinforcing its role as a biomarker. This antibody provides precise detection for researchers investigating tumor biology, hormone regulation, and neuroendocrine physiology.

NSJ Bioreagents offers this Recombinant Chromogranin A antibody to support research in endocrinology, cancer, and neurobiology. Chromogranin A is also described as CHGA antibody, secretogranin I antibody, neuroendocrine marker antibody, and parathyroid secretory protein antibody, illustrating the multiple terms used in scientific literature.

Application Notes

Optimal dilution of the recombinant Chromogranin A antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Recombinant human protein was used as the immunogen for the recombinant Chromogranin A antibody.

Storage

Store the recombinant Chromogranin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).