- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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EGFR Antibody recognizes Epidermal growth factor receptor, a membrane-associated receptor tyrosine kinase that regulates cellular responses to growth factor stimulation. Epidermal growth factor receptor, also widely referred to as EGFR, ErbB1, and HER1, is a central component of epithelial signaling networks that control cell proliferation, survival, migration, and differentiation. EGFR Antibody is used in research settings to study receptor expression and distribution in normal epithelial tissues and in experimental models where growth factor signaling is biologically relevant. The EGFR protein is primarily localized to the plasma membrane, where ligand binding initiates receptor activation and downstream signaling events.
Epidermal growth factor receptor is encoded by the EGFR gene and undergoes ligand-induced dimerization followed by autophosphorylation of intracellular tyrosine residues. These phosphorylation events recruit signaling adaptors that activate pathways such as MAPK, PI3K-AKT, and STAT signaling, coordinating cellular growth and adaptive responses. EGFR Antibody enables investigation of EGFR expression patterns and membrane localization, supporting studies focused on signal transduction, receptor regulation, and epithelial cell biology across a wide range of experimental systems.
EGFR signaling is tightly regulated under physiological conditions, with receptor internalization, recycling, and degradation playing important roles in signal attenuation. Disruption of these regulatory mechanisms can lead to sustained receptor signaling and altered cellular behavior. EGFR Antibody supports research into receptor trafficking, turnover, and spatial regulation at the cell surface and within intracellular compartments, providing insight into how Epidermal growth factor receptor activity is controlled in normal cells.
In cancer-related research, altered expression or dysregulated signaling of Epidermal growth factor receptor is frequently observed in epithelial-derived tumors. EGFR Antibody clone GFR/2341 provides a tool for examining EGFR expression and localization in disease-relevant models, supporting investigations into receptor-driven signaling pathways, tumor biology, and growth factor responsiveness without implying clinical or diagnostic use.
Explore our EGFR Antibody (31G7) page for a broader view of EGFR expression and extensively validated antibody performance across applications.
Titering of the EGFR antibody may be required for optimal performance.
A portion of amino acids 344-492 from the human protein was used as the immunogen for the EGFR antibody.
Store the EGFR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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