KRT4 Antibody / Keratin 4

A KRT4 antibody is used to study the expression of KRT4, also known as Keratin 4, a protein that belongs to the keratin family. Keratins are a group of fibrous structural proteins that are essential for maintaining the integrity and strength of epithelial cells, which are the cells that make up the outer layer of our skin, hair, and nails. KRT4 specifically plays a role in forming the intermediate filaments that provide structural support to these cells. The proper functioning of KRT4 protein is essential for the health and integrity of our epithelial cells. Research has shown that mutations in the KRT4 gene can lead to a variety of skin disorders, such as palmoplantar keratoderma, which is characterized by thickening of the skin on the palms and soles of the feet. Additionally, KRT4 protein has been found to be involved in the process of cell migration, which is essential for wound healing and tissue repair. Understanding the role of KRT4 protein in cellular health has important implications for the development of treatments for various skin disorders and diseases. By targeting the KRT4 protein, researchers may be able to develop new therapies for conditions such as psoriasis, eczema, and other skin disorders that are characterized by abnormalities in keratin production.

 

KRT4 antibody is a crucial tool for researchers studying keratin proteins and their role in various biological processes. This antibody can be utilized in a variety of techniques, including immunohistochemistry, flow cytometry, immunofluorescence, and western blot.

Immunohistochemistry (IHC) is a widely used technique that allows researchers to visualize the presence and localization of specific proteins within tissue samples. By using a KRT4 antibody in IHC experiments, researchers can gain valuable insights into the expression patterns of keratin 4 in different tissues and cell types.

Flow cytometry is another valuable tool for studying protein expression at the single-cell level. By using a KRT4 antibody in flow cytometry experiments, researchers can analyze the expression of keratin 4 in different cell populations, helping to characterize cell types and understand their functions.

Immunofluorescence is a technique that allows researchers to visualize proteins within cells using fluorescently labeled antibodies. By using a KRT4 antibody in immunofluorescence experiments, researchers can gain insights into the subcellular localization of keratin 4 and study its dynamic behavior within cells.

Western blot is a standard technique for detecting and quantifying proteins in cell or tissue lysates. Using a KRT4 antibody in western blot experiments, researchers can confirm the expression of keratin 4 in their samples and analyze its molecular weight and abundance.

A KRT4 antibody is a versatile tool that can be used in a wide range of techniques to study the expression and localization of keratin 4 in various biological samples. By incorporating this antibody into their research, scientists can deepen their understanding of keratin biology and its implications in health and disease.