NSJ Bioreagents

KRT4 Antibody Overview

KRT4 Antibody detects keratin 4, a type II intermediate filament protein expressed in non-keratinizing stratified epithelia. KRT4 is primarily found in the oral mucosa, esophagus, conjunctiva, and other internal epithelial tissues where mechanical resilience is required but keratinization is not extensive. Paired with keratin 13, KRT4 contributes to structural stability, cytoskeletal organization, and barrier function in these tissues.

Mutations in KRT4 cause white sponge nevus, a rare autosomal dominant disorder characterized by thickened, white, folded lesions of the oral mucosa. Beyond genetic disease, altered KRT4 expression is observed in squamous cell carcinomas and other epithelial cancers. The KRT4 Antibody is therefore an essential tool for studying epithelial biology, diagnosing keratin-related disorders, and clarifying tumor pathology.

Because of its restricted expression and disease associations, Keratin 4 Antibody reagents are widely applied across dermatology, oncology, oral biology, and translational research.

Why Choose KRT4 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers KRT4 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, ELISA, and flow cytometry. Each KRT4 Antibody undergoes rigorous validation to confirm specificity for keratin 4 while minimizing cross-reactivity with related keratins.

By choosing a KRT4 Antibody from NSJ Bioreagents, researchers gain access to reagents optimized for reproducibility. Our antibodies provide strong, consistent staining in mucosal tissues, dependable protein detection in lysates, and robust results across multiple experimental platforms. Detailed datasheets, recommended positive controls, and optimized protocols ensure that Keratin 4 Antibody products meet the needs of discovery research and diagnostic pathology alike.

Applications of KRT4 Antibodies

The KRT4 Antibody supports diverse applications in epithelial biology and translational research.

1) Oral Biology and Mucosal Research

KRT4 Antibodies identify epithelial cells of the oral mucosa and esophagus.
The KRT4 Antibody distinguishes keratinizing from non-keratinizing epithelia.
Keratin 4 Antibody reagents support studies of mucosal integrity and wound healing.

2) Genetic Disorders

KRT4 Antibodies detect mutations causing white sponge nevus.
The KRT4 Antibody is used in genetic models to study keratin misfolding and aggregation.
Keratin 4 Antibody reagents validate molecular diagnosis in patient samples.

3) Oncology and Tumor Classification

KRT4 Antibodies are applied in immunohistochemical panels for squamous cell carcinoma.
The KRT4 Antibody helps clarify tumor origin in head and neck cancers.
Keratin 4 Antibody reagents contribute to biomarker discovery for tumor progression.

4) Dermatology and Pathology

KRT4 Antibodies identify mucosal keratin patterns in chronic inflammation.
The KRT4 Antibody distinguishes benign keratin disorders from malignant transformation.

5) Development and Differentiation

KRT4 Antibodies track epithelial differentiation in embryology and tissue models.
The KRT4 Antibody supports studies of keratinocyte lineage specification.

6) Regenerative Medicine

KRT4 Antibodies validate epithelial identity in tissue-engineered mucosa.
The KRT4 Antibody ensures correct differentiation of stem cell-derived epithelia.

7) Translational Medicine and Drug Development

KRT4 Antibodies support therapeutic testing for keratin-related diseases.
The KRT4 Antibody is applied in preclinical models to evaluate mucosal repair strategies.
Keratin 4 Antibody reagents are used in biomarker validation for clinical trials.

Why Are KRT4 Antibodies Important?

Keratin 4 is a specialized marker of non-keratinizing epithelia with significant roles in structural integrity and disease. The KRT4 Antibody enables precise detection and analysis of this protein, while Keratin 4 Antibody reagents more broadly support research in oral biology, oncology, dermatology, and regenerative medicine.

In basic biology, KRT4 Antibodies highlight epithelial cytoskeletal organization. In genetic medicine, the KRT4 Antibody provides insight into white sponge nevus and related disorders. In oncology, Keratin 4 Antibody reagents support tumor diagnosis and classification.

Clinically, KRT4 markers help distinguish mucosal lesions, confirm genetic keratinopathies, and guide cancer diagnostics. By connecting molecular biology with pathology and translational research, the KRT4 Antibody remains a crucial tool for advancing epithelial science and clinical care.

Conclusion

Keratin 4 is a defining marker of non-keratinizing epithelium, essential for tissue integrity and disease diagnosis. The KRT4 Antibody equips researchers and clinicians with a trusted tool for detecting keratin 4, while Keratin 4 Antibody reagents more broadly support advances in mucosal biology, cancer diagnostics, and regenerative research. By linking molecular insights with clinical relevance, these antibodies remain indispensable for biomedical progress and patient health.