KRT2 Antibody / Keratin 2 Antibody

KRT2 Antibody Overview

KRT2 Antibody detects keratin 2, a type II intermediate filament protein expressed in the suprabasal layers of epidermis, particularly in the upper spinous and granular layers of skin. KRT2 provides structural reinforcement in keratinocytes that undergo terminal differentiation, supporting epidermal barrier integrity and resilience.

Mutations in the KRT2 gene are linked to epidermolytic ichthyosis, a rare genetic skin disorder characterized by blistering, hyperkeratosis, and scaling. In addition, altered KRT2 expression patterns are observed in hyperproliferative and inflammatory skin diseases, making this protein an important biomarker in dermatology and pathology. The KRT2 Antibody is therefore a crucial tool for studying epidermal differentiation, genetic keratinopathies, and disease pathology.

Because of its defined expression and disease relevance, Keratin 2 Antibody reagents are applied broadly in dermatology, oncology, and regenerative medicine.

Why Choose KRT2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides KRT2 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, ELISA, and flow cytometry. Each KRT2 Antibody undergoes strict testing for specificity against keratin 2 and minimal cross-reactivity with other keratins.

By choosing a KRT2 Antibody from NSJ Bioreagents, researchers gain reagents optimized for reproducibility. Our antibodies produce sharp staining in epidermal tissue, reliable detection in protein assays, and consistent results across diverse applications. With comprehensive datasheets, recommended positive controls, and application guidance, NSJ Bioreagents ensures that Keratin 2 Antibody products support robust, reproducible outcomes in both discovery and clinical studies.

Applications of KRT2 Antibodies

The KRT2 Antibody has broad applications in skin biology, pathology, and translational research.

1) Skin Biology and Differentiation

• KRT2 Antibodies identify suprabasal keratinocytes in differentiated epidermis.

• The KRT2 Antibody supports studies of barrier formation and keratinocyte maturation.

• Keratin 2 Antibody reagents clarify molecular pathways of epidermal organization.

2) Genetic Disorders

• Mutations in KRT2 cause epidermolytic ichthyosis, making KRT2 Antibodies essential research tools.

• The KRT2 Antibody detects disease-associated keratin changes in patient biopsies.

• Keratin 2 Antibody reagents support studies in transgenic models of keratinopathies.

3) Dermatopathology

• KRT2 Antibodies help distinguish keratinization disorders from inflammatory skin diseases.

• The KRT2 Antibody is applied in histology to characterize suprabasal keratin expression.

• Keratin 2 Antibody products aid in diagnosis of keratin-related conditions.

4) Oncology and Tumor Biology

• KRT2 Antibodies detect altered expression in squamous cell carcinoma.

• The KRT2 Antibody helps clarify keratin remodeling in tumor progression.

• Keratin 2 Antibody reagents support biomarker discovery in skin cancers.

5) Inflammatory Skin Disease

• KRT2 Antibodies highlight keratin expression changes in psoriasis and eczema.

• The KRT2 Antibody helps clarify immune–epithelial interactions in chronic disease.

6) Regenerative Medicine

• KRT2 Antibodies validate keratinocyte differentiation in stem cell models.

• The KRT2 Antibody confirms suprabasal identity in engineered skin tissue.

7) Translational Medicine and Drug Development

• KRT2 Antibodies are used in preclinical models of epidermolytic ichthyosis.

• The KRT2 Antibody supports biomarker validation in dermatology clinical trials.

• Keratin 2 Antibody reagents help assess drug effects on epidermal differentiation.

Why Are KRT2 Antibodies Important?

Keratin 2 plays a specialized role in suprabasal epidermis, linking differentiation to barrier function. The KRT2 Antibody provides researchers with precise detection of this keratin, while Keratin 2 Antibody reagents more broadly support research across dermatology, oncology, genetics, and regenerative biology.

In basic biology, KRT2 Antibodies clarify keratinocyte maturation and barrier formation. In disease research, the KRT2 Antibody highlights genetic keratinopathies such as epidermolytic ichthyosis. In oncology, Keratin 2 Antibody tools provide insights into tumor differentiation and classification.

Clinically, KRT2 markers are applied to diagnose genetic keratin disorders, characterize inflammatory skin disease, and support cancer diagnostics. The KRT2 Antibody connects molecular insights with clinical applications, ensuring progress in both research and patient care.

Conclusion

Keratin 2 is a suprabasal epidermal marker with critical roles in skin differentiation, genetic disease, and pathology. The KRT2 Antibody equips scientists and clinicians with a dependable tool for detecting keratin 2, while Keratin 2 Antibody reagents more broadly support discoveries in dermatology, oncology, and regenerative research. By bridging molecular biology with clinical applications, these antibodies remain indispensable for advancing skin science and patient health.