KRT12 Antibody / Keratin 12 Antibody

KRT12 Antibody Overview

KRT12 Antibody detects keratin 12, a type I intermediate filament protein expressed specifically in the corneal epithelium. Partnering with keratin 3, KRT12 forms the essential cytoskeletal framework that maintains corneal transparency, strength, and barrier integrity. This keratin pairing protects the cornea against mechanical stress, pathogens, and environmental insults, ensuring normal vision and ocular health.

Mutations in KRT12 cause Meesmann corneal dystrophy, a rare hereditary condition characterized by microcysts, corneal fragility, and progressive vision impairment. Because of its highly restricted expression and strong disease association, the KRT12 Antibody is indispensable for corneal biology, pathology, and regenerative medicine research.

Keratin 12 Antibody reagents are applied across ophthalmology, stem cell biology, and translational studies to study corneal epithelial biology and disease.

Why Choose KRT12 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides KRT12 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each KRT12 Antibody undergoes rigorous testing to confirm specificity for keratin 12 while minimizing cross-reactivity with related corneal keratins.

By selecting a KRT12 Antibody from NSJ Bioreagents, scientists gain reagents optimized for reproducibility. Our antibodies provide sharp staining of corneal epithelial cells, consistent detection in protein assays, and strong performance across multiple platforms. With comprehensive datasheets, recommended controls, and optimized protocols, NSJ Bioreagents ensures that Keratin 12 Antibody products deliver clarity and confidence in both basic research and clinical studies.

Applications of KRT12 Antibodies

The KRT12 Antibody has broad utility across ophthalmology, regenerative biology, and translational research.

1) Corneal Biology

• KRT12 Antibodies identify corneal epithelial cells with high specificity.

• The KRT12 Antibody clarifies differentiation and maintenance of corneal epithelium.

• Keratin 12 Antibody reagents support studies of corneal barrier function.

2) Genetic Disease

• Mutations in KRT12 cause Meesmann corneal dystrophy, making KRT12 Antibodies essential in disease research.

• The KRT12 Antibody detects molecular defects in patient-derived samples and models.

• Keratin 12 Antibody products validate biomarkers for genetic corneal dystrophies.

3) Ophthalmology and Diagnostics

• KRT12 Antibodies confirm corneal origin in tissue biopsies.

• The KRT12 Antibody helps distinguish corneal from conjunctival epithelia.

• Keratin 12 Antibody reagents support diagnostic pathology of corneal lesions.

4) Regenerative Medicine and Stem Cell Therapy

• KRT12 Antibodies validate stem cell-derived corneal epithelial cells.

• The KRT12 Antibody ensures correct lineage commitment in regenerative models.

• Keratin 12 Antibody reagents support tissue engineering of corneal grafts.

5) Oncology and Ocular Tumors

• KRT12 Antibodies are applied in ocular tumor pathology to clarify keratin expression.

• The KRT12 Antibody helps distinguish corneal-specific tumors from other ocular neoplasms.

6) Translational Medicine and Drug Discovery

• KRT12 Antibodies support preclinical testing of therapies for corneal dystrophies.

• The KRT12 Antibody validates biomarkers of corneal regeneration in clinical trials.

• Keratin 12 Antibody reagents help assess novel drug effects on corneal repair.

Why Are KRT12 Antibodies Important?

Keratin 12 is a cornea-specific keratin vital for vision and ocular stability. The KRT12 Antibody provides researchers with precise detection of this protein, while Keratin 12 Antibody reagents more broadly support discoveries in ophthalmology, genetics, and regenerative biology.

In basic biology, KRT12 Antibodies clarify corneal differentiation and integrity. In genetic medicine, the KRT12 Antibody provides insight into Meesmann corneal dystrophy. In clinical research, Keratin 12 Antibody tools confirm corneal epithelial identity and validate therapeutic approaches.

Clinically, KRT12 remains one of the most specific markers for corneal epithelium, making the KRT12 Antibody an essential tool for diagnostics and translational studies. By connecting molecular biology with ophthalmic care, these antibodies advance precision medicine approaches in vision science.

Conclusion

Keratin 12 is a highly specific corneal keratin with roles in epithelial stability, genetic disease, and regenerative therapy. The KRT12 Antibody equips scientists and clinicians with a dependable tool for detecting keratin 12 expression, while Keratin 12 Antibody reagents more broadly support research in ophthalmology, corneal biology, and translational medicine. By bridging basic research with clinical application, these antibodies remain indispensable for advancing eye science and improving patient outcomes.