Cytokeratin 9 Antibody / CK9 Antibody

Cytokeratin 9 Antibody Overview

Cytokeratin 9 Antibody reagents target keratin 9 (KRT9), an intermediate filament protein primarily expressed in the suprabasal layers of the epidermis of palms and soles. As a type I cytokeratin, KRT9 plays a structural role in maintaining epithelial integrity, supporting mechanical stability in regions exposed to friction and stress. Unlike many cytokeratins that show broad distribution, KRT9 expression is highly restricted to palmoplantar skin, making it a valuable tissue-specific marker.

Mutations in KRT9 are causative for epidermolytic palmoplantar keratoderma (EPPK), a hereditary skin disorder characterized by thickened and blistered skin on the palms and soles. The Cytokeratin 9 Antibody is therefore indispensable for studying skin differentiation, keratin-related disorders, and epithelial pathology. Meanwhile, the CK9 Antibody provides broader support in dermatology, developmental biology, and translational medicine.

Why Choose Cytokeratin 9 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers Cytokeratin 9 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each Cytokeratin 9 Antibody undergoes stringent quality control to ensure high specificity and reproducibility in skin-focused applications.

By selecting Cytokeratin 9 Antibodies from NSJ Bioreagents, researchers gain access to reagents optimized for reliability and clarity. Our antibodies provide strong, specific staining in palmoplantar epidermis, consistent detection in protein lysates, and dependable results across experimental platforms. Detailed datasheets, recommended controls, and validated protocols further enhance confidence in reproducibility.

Applications of Cytokeratin 9 Antibodies

The Cytokeratin 9 Antibody has focused but highly impactful applications in skin biology and disease research.

1) Dermatology and Skin Biology

• Cytokeratin 9 Antibodies confirm tissue-specific expression in palms and soles.

• The Cytokeratin 9 Antibody highlights suprabasal keratinocyte differentiation.

• CK9 Antibody reagents support mapping of keratin distribution in normal and diseased skin.

2) Keratin Disorders

• Cytokeratin 9 Antibodies are central to research on epidermolytic palmoplantar keratoderma.

• The Cytokeratin 9 Antibody detects altered expression or stability caused by KRT9 mutations.

• CK9 Antibody tools support translational studies on keratinopathy mechanisms.

3) Oncology and Tumor Biology

• Cytokeratin 9 Antibodies are applied in pathology to help distinguish skin tumors.

• The Cytokeratin 9 Antibody validates epithelial lineage in rare keratin-expressing cancers.

4) Developmental and Stem Cell Biology

• Cytokeratin 9 Antibodies clarify epidermal lineage commitment during embryogenesis.

• The Cytokeratin 9 Antibody supports research into epithelial differentiation in vitro.

• CK9 Antibody tools help validate palmoplantar keratinocyte differentiation in stem cell models.

5) Pathology and Diagnostics

• Cytokeratin 9 Antibodies confirm palmoplantar tissue origin in biopsies.

• The Cytokeratin 9 Antibody supports dermatopathology panels for keratin disorders.

• CK9 Antibody reagents contribute to diagnostic clarity in rare epidermal diseases.

6) Translational and Clinical Research

• Cytokeratin 9 Antibodies are applied in biomarker discovery for inherited keratinopathies.

• The Cytokeratin 9 Antibody supports translational research into targeted therapies for EPPK.

• CK9 Antibody tools provide reproducibility in clinical research studies.

Why Are Cytokeratin 9 Antibodies Important?

KRT9 represents a unique tissue-specific cytokeratin with major clinical relevance. The Cytokeratin 9 Antibody enables precise detection of this protein, supporting dermatology, developmental biology, and pathology. The CK9 Antibody complements these efforts by expanding applications across diagnostics and translational medicine.

In basic skin biology, Cytokeratin 9 Antibodies confirm tissue-specific expression and keratinocyte differentiation. In disease research, the Cytokeratin 9 Antibody highlights keratinopathies such as epidermolytic palmoplantar keratoderma. In oncology and pathology, CK9 Antibody reagents support lineage confirmation in epithelial tumors.

Clinically, accurate detection of KRT9 is vital for diagnosing hereditary keratin disorders and distinguishing palmoplantar pathology from other dermatologic conditions. By ensuring specificity and reproducibility, the Cytokeratin 9 Antibody bridges laboratory science with diagnostic and translational medicine.

Conclusion

Cytokeratin 9 is a highly specific marker of palmoplantar skin with important roles in epithelial stability and disease. The Cytokeratin 9 Antibody equips researchers and clinicians with a validated reagent for detecting KRT9, while the CK9 Antibody provides broader support in dermatology, pathology, and translational medicine. By ensuring consistent performance, these antibodies remain indispensable for advancing keratin research and improving clinical care.