Cytokeratin 4 Antibody / CK4 Antibody

Cytokeratin 4 Antibody Overview

Cytokeratin 4 Antibody reagents target keratin 4 (KRT4), a type II intermediate filament protein expressed in non-keratinizing stratified epithelia, such as the oral mucosa, esophagus, and conjunctiva. Together with its type I partner keratin 13, KRT4 contributes to epithelial structural integrity, resistance to mechanical stress, and tissue resilience in mucosal environments.

Mutations in KRT4 are associated with white sponge nevus, a benign but chronic epithelial disorder that causes thickened, folded lesions in the oral and other mucosal surfaces. Because of its restricted expression, KRT4 serves as a reliable biomarker for distinguishing non-keratinizing squamous epithelia from keratinizing tissues. The Cytokeratin 4 Antibody is therefore indispensable for studying oral pathology, epithelial biology, and keratin-associated diseases. The CK4 Antibody also supports applications in developmental biology, oncology, and translational research.

Why Choose Cytokeratin 4 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers Cytokeratin 4 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each Cytokeratin 4 Antibody is rigorously tested to ensure specificity, reproducibility, and minimal cross-reactivity in complex tissue samples.

By choosing Cytokeratin 4 Antibodies from NSJ Bioreagents, researchers gain tools optimized for reproducibility and clarity. Our antibodies deliver strong epithelial staining in oral and mucosal tissues, reproducible detection in protein lysates, and dependable performance across experimental platforms. With detailed datasheets, suggested controls, and validated protocols, NSJ Bioreagents ensures confidence in both discovery and clinical applications.

Applications of Cytokeratin 4 Antibodies

The Cytokeratin 4 Antibody supports a focused but impactful set of research and diagnostic uses.

1) Oral and Mucosal Biology

• Cytokeratin 4 Antibodies highlight expression in non-keratinizing squamous epithelia.

• The Cytokeratin 4 Antibody supports studies of epithelial integrity in the oral cavity and esophagus.

• CK4 Antibody reagents map differentiation patterns in mucosal tissues.

2) Genetic Disorders and Pathology

• Cytokeratin 4 Antibodies are used to detect mutations linked to white sponge nevus.

• The Cytokeratin 4 Antibody supports research into structural keratinopathies.

• CK4 Antibody reagents help validate diagnostic biomarkers for hereditary mucosal disorders.

3) Oncology and Tumor Biology

• Cytokeratin 4 Antibodies clarify epithelial lineage in head and neck squamous cell carcinomas.

• The Cytokeratin 4 Antibody helps differentiate keratinizing from non-keratinizing carcinomas.

• CK4 Antibody reagents support biomarker validation in oral oncology.

4) Developmental and Stem Cell Biology

• Cytokeratin 4 Antibodies monitor epithelial lineage specification in embryogenesis.

• The Cytokeratin 4 Antibody validates epithelial differentiation in stem cell and organoid models.

• CK4 Antibody reagents support regenerative medicine studies involving mucosal repair.

5) Inflammation and Infectious Disease

• Cytokeratin 4 Antibodies highlight epithelial responses in chronic inflammation of the oral mucosa.

• The Cytokeratin 4 Antibody supports research into pathogen–epithelial interactions in mucosal tissues.

6) Translational and Clinical Research

• Cytokeratin 4 Antibodies are validated in biomarker-driven studies of mucosal pathology.

• The Cytokeratin 4 Antibody contributes to diagnostic clarity in clinical trials.

• CK4 Antibody reagents provide reproducibility in translational workflows.

Why Are Cytokeratin 4 Antibodies Important?

KRT4 plays essential roles in maintaining the stability and resilience of mucosal epithelia. The Cytokeratin 4 Antibody equips researchers with a precise tool for detecting this keratin, while the CK4 Antibody extends applications across diagnostics, oncology, and developmental biology.

In oral pathology, Cytokeratin 4 Antibodies identify abnormalities linked to white sponge nevus and epithelial dysplasia. In oncology, the Cytokeratin 4 Antibody helps classify squamous cell carcinomas of the head and neck. In developmental biology, CK4 Antibody reagents support studies of epithelial lineage specification.

Clinically, accurate detection of KRT4 is important for distinguishing non-keratinizing epithelia from keratinizing counterparts. Cytokeratin 4 Antibodies provide reproducibility and diagnostic confidence, bridging laboratory research with clinical practice.

Conclusion

Cytokeratin 4 is a defining marker of non-keratinizing stratified epithelia, with critical roles in mucosal biology and disease. The Cytokeratin 4 Antibody provides a validated reagent for detecting KRT4 in oral pathology, developmental biology, and oncology, while the CK4 Antibody supports broader applications in translational medicine. By ensuring specificity and reproducibility, these antibodies remain indispensable for advancing keratin research and improving clinical diagnostics.