Aquaporin 2 Antibody / AQP2 Antibody

Aquaporin 2 Antibody Overview

Aquaporin 2 Antibody reagents target AQP2, a water channel that plays a pivotal role in renal water reabsorption and systemic fluid balance. AQP2 is expressed in the principal cells of the collecting ducts in the kidney and is uniquely regulated by vasopressin (antidiuretic hormone, ADH). Upon vasopressin stimulation, AQP2 translocates to the apical membrane, allowing water to be reabsorbed into the bloodstream. This process is central to maintaining plasma osmolality and hydration status.

Mutations or dysregulation of AQP2 expression are associated with nephrogenic diabetes insipidus, polyuria, and electrolyte imbalance. Because of its essential role in kidney physiology and disease, the Aquaporin 2 Antibody is a key reagent for nephrology research and translational medicine. The AQP2 Antibody complements these studies by providing validated tools for multiple applications.

Why Choose Aquaporin 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Aquaporin 2 Antibodies validated for immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and ELISA. Each Aquaporin 2 Antibody undergoes rigorous testing for specificity, reproducibility, and compatibility across diverse experimental platforms.

By choosing Aquaporin 2 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for sensitivity and reliability. Our antibodies deliver strong detection in kidney tissue sections, reproducible results in protein lysates, and robust performance in translational studies. Comprehensive datasheets, validated controls, and optimized protocols further support reproducibility across laboratory and clinical pipelines.

Applications of Aquaporin 2 Antibodies

The Aquaporin 2 Antibody supports wide-ranging applications across kidney physiology, endocrinology, and translational medicine.

1) Kidney and Renal Research

• Aquaporin 2 Antibodies detect AQP2 in collecting duct principal cells.

• The Aquaporin 2 Antibody supports studies of vasopressin-regulated water transport.

• AQP2 Antibody reagents validate biomarkers for renal water handling.

2) Diabetes Insipidus and Hydration Disorders

• Aquaporin 2 Antibodies clarify pathophysiology of nephrogenic and central diabetes insipidus.

• The Aquaporin 2 Antibody supports research into therapeutic interventions.

• AQP2 Antibody reagents validate diagnostic assays for water balance disorders.

3) Endocrinology and Hormone Regulation

• Aquaporin 2 Antibodies track vasopressin signaling pathways.

• The Aquaporin 2 Antibody supports studies of cyclic AMP and protein kinase A regulation.

• AQP2 Antibody reagents provide insights into endocrine control of renal physiology.

4) Pharmacology and Therapeutic Development

• Aquaporin 2 Antibodies support drug discovery targeting vasopressin pathways.

• The Aquaporin 2 Antibody validates pharmacodynamic endpoints in preclinical models.

• AQP2 Antibody reagents contribute to biomarker-driven clinical trials.

5) Comparative and Developmental Biology

• Aquaporin 2 Antibodies detect expression across species and developmental stages.

• The Aquaporin 2 Antibody supports evolutionary studies of water transport regulation.

• AQP2 Antibody reagents clarify developmental roles in renal maturation.

6) Translational and Clinical Research

• Aquaporin 2 Antibodies are integrated into nephrology and endocrinology studies.

• The Aquaporin 2 Antibody supports diagnostics for kidney water transport disorders.

• AQP2 Antibody reagents ensure reproducibility across translational pipelines.

Why Are Aquaporin 2 Antibodies Important?

AQP2 is a vasopressin-regulated water channel essential for systemic fluid balance. The Aquaporin 2 Antibody equips researchers with validated tools to study kidney water reabsorption, hydration disorders, and endocrine regulation, while the AQP2 Antibody expands applications across diagnostics and translational medicine.

In nephrology, Aquaporin 2 Antibodies clarify collecting duct water transport and disease mechanisms. In endocrinology, the Aquaporin 2 Antibody provides insights into hormone regulation of renal physiology. In translational studies, AQP2 Antibody reagents validate biomarkers for diabetes insipidus and related disorders.

Clinically, AQP2 is both a biomarker and therapeutic target, with potential applications in diagnostics and drug development. Reliable Aquaporin 2 Antibodies ensure reproducibility and accuracy, bridging basic science with clinical research and patient care.

Conclusion

AQP2 is a critical aquaporin for renal water transport and systemic hydration. The Aquaporin 2 Antibody provides validated reagents for studying kidney physiology, vasopressin signaling, and water balance disorders, while the AQP2 Antibody extends applications into diagnostics and translational medicine. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing kidney research and improving outcomes in hydration disorders.