Aquaporin 2 Antibody / Vasopressin-Regulated Water Channel Antibody

Aquaporin 2 Antibody Overview

Aquaporin 2 (AQP2) is a vasopressin-regulated water channel protein that plays a central role in maintaining water balance by controlling water reabsorption in the kidney collecting duct. Unlike many aquaporins that are constitutively expressed at the plasma membrane, AQP2 undergoes dynamic trafficking in response to antidiuretic hormone (vasopressin), which regulates its insertion into the apical membrane of collecting duct epithelial cells. Aquaporin 2 antibody reagents are widely used to study renal physiology, water homeostasis, and hormone-regulated membrane transport.

Aquaporin 2 antibody, also referred to as AQP2 antibody or collecting duct water channel antibody, is commonly used to detect expression in kidney tissues, where AQP2 is highly enriched in principal cells of the collecting duct. Upon vasopressin stimulation, AQP2 translocates from intracellular vesicles to the apical membrane, enabling increased water permeability and reabsorption. This regulated trafficking produces distinct localization patterns that can be visualized using Aquaporin 2 antibody in tissue and cellular studies.

AQP2 is essential for proper urine concentration and systemic water balance. Dysregulation of AQP2 expression or trafficking is associated with disorders such as nephrogenic diabetes insipidus, where impaired water reabsorption leads to excessive urine output. Aquaporin 2 antibody enables investigation of these mechanisms by allowing researchers to monitor protein expression levels and subcellular localization in renal tissues and experimental models.

In addition to its role in kidney physiology, AQP2 is also studied in the context of hormonal signaling pathways that regulate membrane protein trafficking. Its responsiveness to vasopressin makes it a valuable model for understanding signal-dependent protein redistribution within cells. Aquaporin 2 antibody supports studies of intracellular trafficking, membrane insertion, and epithelial transport regulation.

Due to its highly specific expression pattern and regulated localization, AQP2 serves as a key marker of collecting duct function and renal water handling. Aquaporin 2 antibody provides a powerful tool for studying kidney biology, endocrine regulation, and disorders of water balance.

👉 For a full selection of AQP2 antibody products and formats, visit our AQP2 antibody page.

Aquaporin 2 Antibody in Kidney Physiology

AQP2 is localized to collecting duct principal cells, where it regulates water permeability in response to vasopressin signaling.

Aquaporin 2 Antibody in Water Reabsorption

Aquaporin 2 antibody enables analysis of hormone-dependent water transport mechanisms critical for maintaining fluid balance.

Aquaporin 2 Antibody in Renal Disease

Altered AQP2 expression or trafficking is linked to disorders such as nephrogenic diabetes insipidus, making it a key target in kidney research.

A selection of AQP2 antibody products is shown below to support a range of research applications.