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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Fc gamma receptor II (FCGR2), commonly known as CD32, is a family of low-affinity IgG Fc receptors involved in immune complex recognition, leukocyte activation, and regulation of antibody-mediated immune responses. CD32 Antibody / Low-Affinity Fc Gamma Receptor is useful for studying innate immune signaling, Fc receptor biology, B-cell regulation, phagocytosis, and inflammatory pathway activation. CD32 receptors are encoded by closely related FCGR2 family genes including FCGR2A, FCGR2B, and FCGR2C, which together regulate activating and inhibitory Fc-mediated immune signaling pathways.
CD32 antibody, also referred to as FCGR2 antibody, Fc gamma receptor II antibody, or FCGR2A/FCGR2B antibody in the literature, recognizes a transmembrane Fc receptor family expressed primarily on monocytes, macrophages, neutrophils, dendritic cells, B lymphocytes, platelets, and additional immune-associated cell populations. CD32 receptors bind IgG-containing immune complexes with lower affinity than CD64/FCGR1A and contribute to immune complex clearance, cytokine production, antigen presentation, and regulation of inflammatory signaling.
Different CD32 isoforms mediate distinct biologic functions. FCGR2A primarily functions as an activating receptor involved in phagocytosis and leukocyte activation, while FCGR2B serves as a major inhibitory Fc receptor that suppresses excessive immune activation and maintains immune tolerance. Through balanced activating and inhibitory signaling, CD32 receptors regulate antibody-dependent immune responses and contribute to control of inflammation, infection, and autoimmunity.
CD32 expression has been widely studied in sepsis, autoimmune disease, hematologic malignancy, chronic inflammation, and tumor immunology. Altered FCGR2 signaling may influence susceptibility to infection, antibody therapy responses, immune complex-mediated tissue injury, and regulation of B-cell activation pathways. CD32 additionally contributes to Fc-mediated signaling mechanisms involved in macrophage activation and innate immune regulation.
FCGR2 family proteins are encoded within the Fc receptor gene cluster on chromosome 1q23 and produce glycosylated type I transmembrane receptors containing extracellular immunoglobulin-like domains responsible for IgG binding. CD32 proteins localize predominantly to the plasma membrane where they regulate Fc receptor signaling and leukocyte communication pathways. Because Fc receptor biology is central to both innate and adaptive immunity, CD32 remains an important target in immunology, inflammation, and therapeutic antibody research.
This goat polyclonal CD32 antibody is suitable for research applications involving flow cytometry, western blotting, immunophenotyping, and immune receptor signaling analysis. The antibody supports detection of endogenous CD32/FCGR2-associated receptor expression in immune-related cell populations relevant to Fc-mediated inflammatory and leukocyte activation pathways.
Explore the broader CD Antibodies page for additional antibodies targeting leukocyte differentiation markers, immune receptors, and cell surface proteins involved in innate and adaptive immune signaling pathways.
Optimal dilution of the CD32 Antibody / Low-Affinity Fc Gamma Receptor should be determined by the researcher.
Amino acids PDALEEPDDQNRI were used as the immunogen for this CD32 antibody.
Aliquot and store the CD32 antibody at -20oC.
FCGR2 antibody, Fc gamma receptor II antibody, FCGR2A antibody, FCGR2B antibody, CD32 immune receptor antibody
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