- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD32 Antibody / FCGR2A [clone 7.3] (V2495)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2495-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V2495-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V2495SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 7.3 |
| Purity | Protein G affinity chromatography |
| UniProt | P12318 |
| Localization | Cytoplasm, plasma membrane |
| Applications | Functional Studies (order BSA/sodium Azide-free Format) : Immunofluorescence : 0.5-1ug/ml |
| Limitations | This CD32 antibody is available for research use only. |
|
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This CD32 Antibody clone 7.3 reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
Researchers studying Fc receptor signaling, immune complex recognition, and leukocyte activation pathways may also benefit from the CD32 Antibody / Low-Affinity Fc Gamma Receptor page featuring western blot, immunohistochemistry, immunofluorescence, and flow cytometry validation data for endogenous FCGR2 detection.
Optimal dilution of the CD32 antibody should be determined by the researcher.
K562 and FcgRII+L cells were used as the immunogen for the CD32 antibody.
Store the CD32 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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