Alpha Actinin 2 Antibody / ACTN2 Antibody

Alpha Actinin 2 Antibody Overview

Alpha Actinin 2 Antibody reagents target alpha-actinin-2 (ACTN2), a cytoskeletal protein critical for muscle structure and function. ACTN2 belongs to the alpha-actinin family of actin-binding proteins, which organize actin filaments into bundles and link them to other structural and signaling molecules.

Alpha-actinin-2 is highly expressed in striated muscle, particularly cardiac and skeletal muscle. It is concentrated at the Z-discs, where it crosslinks actin filaments and anchors sarcomeric components. This structural role is fundamental to muscle contractility, integrity, and signaling. Beyond structural support, ACTN2 interacts with ion channels and signaling complexes, influencing excitation–contraction coupling and cellular communication.

Mutations in ACTN2 have been linked to inherited cardiomyopathies, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Abnormal expression is also implicated in skeletal muscle disorders. Because of its structural and disease relevance, the Alpha Actinin 2 Antibody is an indispensable tool for muscle physiology, cardiology, and translational medicine. The ACTN2 Antibody complements these studies with reliable detection across diverse platforms.

Why Choose Alpha Actinin 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Alpha Actinin 2 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous testing for specificity, reproducibility, and assay performance.

Benefits include:

• Muscle-Specific Relevance: Validated in cardiac and skeletal tissues.

• Cross-Platform Validation: Reliable results across multiple assay types.

• Reproducibility: Guaranteed batch-to-batch consistency.

• Detailed Documentation: Datasheets with protocols and suggested controls.

• Translational Value: Applicable in both research and biomarker-driven clinical studies.

By selecting NSJ Bioreagents, researchers gain confidence that the Alpha Actinin 2 Antibody will perform consistently in both exploratory and translational pipelines.

Applications of Alpha Actinin 2 Antibodies

The Alpha Actinin 2 Antibody supports diverse applications in muscle biology, cardiology, and translational medicine.

1) Muscle Structure and Sarcomere Biology

• Detect ACTN2 at Z-discs in striated muscle.

• Support studies of actin filament organization.

• Clarify roles in sarcomeric integrity and contractile function.

• Provide markers for skeletal and cardiac muscle differentiation.

2) Cardiac Development and Disease

• Alpha Actinin 2 Antibody detects ACTN2 expression in cardiomyocytes.

• Supports research into cardiac morphogenesis.

• Clarifies how ACTN2 mutations cause hypertrophic or dilated cardiomyopathy.

• Provides translational biomarkers for cardiac disease research.

3) Skeletal Muscle Biology

• Detect ACTN2 expression in skeletal myofibers.

• Support studies of muscle growth, repair, and regeneration.

• Provide biomarkers for muscular dystrophies and myopathies.

• Extend into exercise physiology and sports medicine research.

4) Ion Channel and Signaling Interactions

• Alpha Actinin 2 Antibody supports studies of ACTN2 interactions with ion channels.

• Clarify roles in excitation–contraction coupling.

• Provide translational markers for electrophysiology and arrhythmia research.

• Extend into mechanotransduction and signaling biology.

5) Inherited Cardiomyopathies

• Detect ACTN2 mutations associated with hypertrophic cardiomyopathy.

• Provide biomarkers for genetic screening and translational research.

• Support functional studies of ACTN2 variants in patient-derived models.

• Extend into personalized cardiology pipelines.

6) Regenerative Medicine and Stem Cell Biology

• Alpha Actinin 2 Antibody supports studies of induced pluripotent stem cells (iPSCs) differentiating into cardiomyocytes.

• Validate sarcomere assembly during differentiation.

• Provide biomarkers for cardiac regeneration therapies.

• Extend into translational tissue engineering.

7) Translational and Clinical Research

• Alpha Actinin 2 Antibody detects altered expression in cardiomyopathy biopsies.

• Supports biomarker-driven stratification of patients.

• Provides reproducibility for clinical assay development.

• Bridges basic biology with translational medicine.

Why Are Alpha Actinin 2 Antibodies Important?

ACTN2 is more than a structural protein—it is a molecular hub integrating cytoskeletal stability, ion channel regulation, and signaling. The Alpha Actinin 2 Antibody allows researchers to study these diverse functions in health and disease.

In muscle physiology, it clarifies sarcomeric organization and contractility. In cardiology, it reveals how mutations lead to inherited cardiomyopathies and arrhythmias. In skeletal muscle biology, it supports research into repair, growth, and dystrophy. In regenerative medicine, it validates cardiomyocyte differentiation and tissue engineering.

Clinically, ACTN2 is emerging as a biomarker for genetic cardiomyopathy. Reliable ACTN2 Antibody reagents ensure reproducibility across discovery, translational, and clinical research pipelines.

Conclusion

Alpha-actinin-2 is a critical cytoskeletal protein anchoring sarcomeres, regulating ion channels, and linking structural and signaling pathways. The Alpha Actinin 2 Antibody provides validated tools for muscle biology, cardiology, and regenerative medicine, while the ACTN2 Antibody complements these applications across translational pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing research into muscle physiology and inherited cardiomyopathies.