ACTN2 Antibody / Alpha Actinin 2 Antibody

ACTN2 Antibody Overview

ACTN2 Antibody reagents target alpha-actinin-2 (ACTN2), a cytoskeletal protein critical for the assembly and function of striated muscle. ACTN2 belongs to the alpha-actinin family of actin-binding proteins that organize thin filaments, stabilize sarcomeres, and connect actin to diverse structural and signaling proteins.

Alpha-actinin-2 is localized predominantly at the Z-discs of cardiac and skeletal muscle, where it crosslinks actin filaments and anchors contractile units. In addition to its mechanical role, ACTN2 interacts with signaling complexes and ion channels, influencing excitation–contraction coupling and cellular communication.

Mutations in ACTN2 are associated with inherited cardiomyopathies such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmias. Altered ACTN2 expression has also been implicated in skeletal muscle disorders. Because of its essential structural and disease-related functions, the ACTN2 Antibody is an indispensable reagent for cardiovascular biology, skeletal muscle physiology, and translational pipelines. The Alpha Actinin 2 Antibody supports these studies with complementary detection across diverse platforms.

Why Choose ACTN2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides ACTN2 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous quality control to ensure specificity, reproducibility, and assay reliability.

Key benefits include:

• Muscle Relevance: Validated in cardiac and skeletal muscle tissues.

• Cross-Platform Use: Reliable performance across multiple assay types.

• Batch Consistency: Ensures reproducibility in long-term studies.

• Comprehensive Support: Datasheets with protocols, recommended controls, and validation images.

• Translational Value: Suitable for discovery, biomarker, and clinical applications.

By selecting NSJ Bioreagents, researchers can trust the ACTN2 Antibody for precise and reproducible results in studies of muscle structure and disease.

Applications of ACTN2 Antibodies

The ACTN2 Antibody supports wide-ranging applications in cardiac research, skeletal muscle biology, and translational medicine.

1) Cardiac Structure and Physiology

• Detect ACTN2 expression in cardiomyocytes and Z-discs.

• Support studies of sarcomere assembly and contractile function.

• Clarify structural roles in excitation–contraction coupling.

• Provide translational biomarkers for cardiac remodeling.

2) Cardiomyopathy and Cardiac Disease

• ACTN2 Antibody detects mutations linked to hypertrophic and dilated cardiomyopathy.

• Supports studies of arrhythmogenic remodeling.

• Provides biomarkers for translational cardiology and patient stratification.

• Extends into iPSC-derived cardiomyocyte models for personalized medicine.

3) Skeletal Muscle Biology

• Detect ACTN2 expression in skeletal muscle fibers.

• Support studies of muscle growth, injury repair, and regeneration.

• Provide biomarkers for dystrophies and congenital myopathies.

• Extend into exercise physiology and performance research.

4) Cytoskeleton and Sarcomere Assembly

• ACTN2 Antibody highlights actin filament crosslinking.

• Supports mechanistic studies of sarcomeric integrity.

• Provides biomarkers for contractile apparatus stability.

• Extends into mechanotransduction and signaling research.

5) Ion Channel and Signaling Complexes

• Detect interactions of ACTN2 with ion channels such as Nav1.5.

• Clarify links between cytoskeletal organization and electrophysiology.

• Provide translational markers for arrhythmia research.

• Extend into cardiac electrophysiology pipelines.

6) Development and Regeneration

• ACTN2 Antibody detects expression during cardiac and skeletal development.

• Supports studies of embryonic morphogenesis.

• Provides biomarkers for cardiac regeneration and stem cell biology.

• Extends into translational regenerative medicine.

7) Translational and Clinical Research

• Detect ACTN2 expression in cardiomyopathy biopsies.

• Provide reproducibility in biomarker-driven clinical studies.

• Support diagnostics for genetic muscle disease.

• Bridge basic muscle biology with translational pipelines.

Why Are ACTN2 Antibodies Important?

ACTN2 is not only a structural anchor but also a molecular integrator of cytoskeletal mechanics, ion channel regulation, and signaling pathways. The ACTN2 Antibody provides researchers with validated tools to study these functions in both health and disease.

In cardiology, it clarifies how mutations disrupt sarcomere stability and lead to cardiomyopathy. In skeletal muscle biology, it supports studies of muscle regeneration and disease progression. In developmental biology, it defines ACTN2’s role in early sarcomere assembly. In translational medicine, the Alpha Actinin 2 Antibody ensures reproducibility for biomarker-driven studies.

Clinically, ACTN2 mutations are emerging diagnostic markers for inherited cardiomyopathies and arrhythmias. Reliable ACTN2 Antibody reagents enable researchers to connect genetic findings with functional outcomes and therapeutic approaches.

Conclusion

ACTN2 anchors thin filaments at the Z-disc, orchestrating contractile function and signaling in striated muscle. The ACTN2 Antibody provides validated tools for cardiac and skeletal muscle research, while the Alpha Actinin 2 Antibody complements these studies across translational pipelines. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain essential for advancing muscle biology and cardiomyopathy research.