Acetyl-CoA carboxylase 2 Antibody / ACACB Antibody

Acetyl-CoA Carboxylase 2 Antibody Overview

Acetyl-CoA Carboxylase 2 Antibody reagents target ACC2 (ACACB), an isoform of acetyl-CoA carboxylase that plays a central role in fatty acid metabolism. ACC2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a key intermediate that regulates lipid synthesis and oxidation.

Unlike ACC1 (ACACA), which supports fatty acid synthesis in lipogenic tissues, ACC2 is primarily expressed in oxidative tissues such as skeletal muscle and heart. Here, its role is regulatory: malonyl-CoA produced by ACC2 inhibits carnitine palmitoyltransferase I (CPT1), the enzyme controlling mitochondrial fatty acid uptake. By modulating fatty acid oxidation, ACC2 acts as a gatekeeper for energy homeostasis, balancing lipid storage and utilization.

Dysregulated ACC2 activity has been linked to obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. Because of its importance in metabolic control, the Acetyl-CoA Carboxylase 2 Antibody is indispensable for lipid metabolism research, energy regulation studies, and translational medicine. The ACACB Antibody provides reproducible detection of ACC2 across diverse assay platforms.

Why Choose Acetyl-CoA Carboxylase 2 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Acetyl-CoA Carboxylase 2 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes stringent quality control for specificity, reproducibility, and assay reliability.

Benefits include:

• Metabolic Relevance: Targets a regulator of fatty acid oxidation.

• Assay Versatility: Validated for multiple platforms, from tissue to serum.

• Reproducibility: Batch-to-batch consistency across long-term studies.

• Comprehensive Support: Datasheets with protocols and recommended controls.

• Translational Value: Applicable to biomarker-driven and clinical research.

By selecting NSJ Bioreagents, scientists can trust the Acetyl-CoA Carboxylase 2 Antibody for accurate and reproducible results in metabolic biology.

Applications of Acetyl-CoA Carboxylase 2 Antibodies

The Acetyl-CoA Carboxylase 2 Antibody supports diverse applications across metabolism, cardiovascular biology, obesity research, and translational pipelines.

1) Lipid Metabolism and Fatty Acid Oxidation

• Detect ACC2 expression in oxidative tissues such as heart and skeletal muscle.

• Support studies of malonyl-CoA regulation of mitochondrial fatty acid uptake.

• Provide biomarkers for energy balance and lipid turnover.

• Extend into translational pipelines for metabolic therapies.

2) Obesity and Insulin Resistance

• Acetyl-CoA Carboxylase 2 Antibody detects altered expression in obesity models.

• Supports research into ACC2’s role in insulin resistance.

• Provides biomarkers for linking obesity to type 2 diabetes.

• Extends into translational endocrinology research.

3) Type 2 Diabetes and Glucose Homeostasis

• Detect ACC2 expression changes during hyperglycemia and insulin resistance.

• Support studies linking fatty acid oxidation to glucose regulation.

• Provide translational markers for diabetes progression.

• Extend into therapeutic discovery targeting ACC2.

4) Cardiovascular Disease and Energetics

• Detect ACC2 in cardiac tissue, where it regulates energy substrate use.

• Support studies of fatty acid oxidation in heart failure.

• Provide biomarkers for metabolic remodeling in cardiomyopathy.

• Extend into translational cardiology pipelines.

5) Skeletal Muscle Biology and Exercise

• Acetyl-CoA Carboxylase 2 Antibody detects ACC2 regulation during exercise.

• Supports studies of endurance adaptations and energy switching.

• Provides biomarkers for muscle fuel preference.

• Extends into sports physiology and metabolic performance research.

6) Pharmacology and Drug Discovery

• ACC2 is a therapeutic target for obesity and diabetes drug development.

• Antibodies validate ACC2 inhibition in preclinical models.

• Provide translational biomarkers for drug efficacy testing.

• Extend into pharmaceutical pipelines for metabolic disease therapy.

7) Translational and Clinical Research

• Acetyl-CoA Carboxylase 2 Antibody supports biomarker studies in metabolic syndrome.

• Provides reproducibility in clinical pipelines linking ACC2 to disease risk.

• Extends into diagnostics for cardiovascular and metabolic disorders.

• Bridges laboratory research with clinical applications.

Why Are Acetyl-CoA Carboxylase 2 Antibodies Important?

ACC2 is a master regulator of lipid oxidation, controlling mitochondrial access to fatty acids and shaping energy homeostasis. The Acetyl-CoA Carboxylase 2 Antibody enables researchers to study ACC2 regulation in tissues, disease states, and therapeutic interventions.

In metabolic research, it clarifies how ACC2 contributes to obesity, diabetes, and insulin resistance. In cardiology, it supports studies of fatty acid metabolism in heart failure. In exercise physiology, it defines how ACC2 activity regulates endurance and fuel preference. In pharmacology, it validates ACC2 as a target for anti-obesity and antidiabetic therapies.

Clinically, ACC2 is a promising biomarker and therapeutic target in metabolic syndrome, cardiovascular disease, and diabetes. Reliable ACACB Antibody reagents ensure reproducibility across laboratory, translational, and clinical pipelines.

Conclusion

ACC2 is a crucial enzyme that regulates fatty acid oxidation and energy balance. The Acetyl-CoA Carboxylase 2 Antibody provides validated tools for obesity, diabetes, cardiovascular, and translational research, while the ACACB Antibody complements these applications across assay platforms. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing metabolic biology and improving clinical outcomes.