Acetyl-CoA carboxylase 1 Antibody / ACACA Antibody

Acetyl-CoA Carboxylase 1 Antibody Overview

Acetyl-CoA Carboxylase 1 Antibody reagents target ACC1 (ACACA), a cytosolic enzyme central to fatty acid biosynthesis. ACC1 catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA, which is subsequently used by fatty acid synthase to elongate carbon chains into long-chain fatty acids. This reaction represents the rate-limiting step in de novo lipogenesis.

ACC1 is highly expressed in lipogenic tissues such as liver and adipose tissue, where it regulates lipid storage, energy balance, and metabolic signaling. Dysregulated ACC1 activity leads to excessive lipid accumulation, contributing to obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and certain cancers.

Because of its critical role in lipogenesis and disease, the Acetyl-CoA Carboxylase 1 Antibody is indispensable for studying metabolism, obesity, and oncology. The ACACA Antibody complements these studies with reproducible detection across multiple assay systems.

Why Choose Acetyl-CoA Carboxylase 1 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Acetyl-CoA Carboxylase 1 Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody is tested for specificity, reproducibility, and assay compatibility.

Key benefits include:

• Metabolic Relevance: Direct detection of ACC1, the key enzyme in fatty acid synthesis.

• Assay Versatility: Validated across tissues, cells, and biochemical assays.

• Reproducibility: Batch-to-batch consistency across studies.

• Technical Documentation: Datasheets include protocols, controls, and validation data.

• Translational Value: Suitable for biomarker discovery and clinical applications.

By choosing NSJ Bioreagents, researchers can trust the Acetyl-CoA Carboxylase 1 Antibody for clarity, specificity, and reproducibility in metabolic research.

Applications of Acetyl-CoA Carboxylase 1 Antibodies

The Acetyl-CoA Carboxylase 1 Antibody supports broad applications in lipid metabolism, obesity, oncology, and translational research.

1) Lipogenesis and Fatty Acid Metabolism

• Detect ACC1 expression in liver and adipose tissues.

• Support studies of malonyl-CoA production and fatty acid elongation.

• Provide biomarkers for de novo lipogenesis.

• Extend into translational metabolic research.

2) Obesity and Metabolic Syndrome

• Acetyl-CoA Carboxylase 1 Antibody detects increased ACC1 activity in obesity.

• Supports studies of adipose tissue dysfunction and lipid accumulation.

• Provides biomarkers for obesity-linked insulin resistance.

• Extends into translational endocrinology pipelines.

3) Non-Alcoholic Fatty Liver Disease (NAFLD)

• Detect ACC1 upregulation in hepatocytes during steatosis.

• Support research into NAFLD progression and metabolic remodeling.

• Provide biomarkers for liver lipid accumulation.

• Extend into translational hepatology research.

4) Oncology and Tumor Metabolism

• Acetyl-CoA Carboxylase 1 Antibody detects ACC1 expression in tumor cells.

• Supports studies of metabolic reprogramming in cancer.

• Provides biomarkers for lipid synthesis-driven tumor growth.

• Extends into translational oncology and therapeutic targeting.

5) Insulin Resistance and Type 2 Diabetes

• Detect altered ACC1 expression in insulin-resistant states.

• Support studies linking lipogenesis to impaired glucose metabolism.

• Provide translational biomarkers for diabetes progression.

• Extend into therapeutic development for metabolic disease.

6) Pharmacology and Drug Discovery

• ACC1 is a validated drug target for anti-obesity and anticancer therapies.

• Antibodies support preclinical studies of ACC1 inhibition.

• Provide biomarkers for drug efficacy in metabolic models.

• Extend into pharmaceutical pipelines targeting lipogenesis.

7) Translational and Clinical Research

• Acetyl-CoA Carboxylase 1 Antibody supports biomarker studies in metabolic disease.

• Provides reproducibility in clinical assays.

• Ensures consistency from discovery research to translational medicine.

• Bridges basic biology with therapeutic development.

Why Are Acetyl-CoA Carboxylase 1 Antibodies Important?

ACC1 is the rate-limiting enzyme for fatty acid biosynthesis, making it a metabolic checkpoint in health and disease. The Acetyl-CoA Carboxylase 1 Antibody equips researchers to study ACC1 activity in tissues, disease models, and translational settings.

In metabolic biology, it clarifies how ACC1 contributes to lipid storage and obesity. In hepatology, it highlights roles in fatty liver disease. In oncology, it reveals how ACC1-driven lipogenesis supports tumor growth. In endocrinology, it connects lipogenesis to insulin resistance and diabetes.

Clinically, ACC1 is both a biomarker and therapeutic target in metabolic syndrome, NAFLD, and cancer. Reliable ACACA Antibody reagents ensure reproducibility, supporting discovery, translational, and clinical research pipelines.

Conclusion

ACC1 is a master regulator of lipogenesis, linking lipid metabolism to obesity, liver disease, and cancer. The Acetyl-CoA Carboxylase 1 Antibody provides validated tools for metabolic, oncological, and translational studies, while the ACACA Antibody complements these applications across diverse assays. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing metabolic biology and therapeutic discovery.