- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Acetyl CoA Carboxylase 1 Antibody / ACACA (RQ7317)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7317 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q13085 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This Acetyl CoA Carboxylase 1 antibody is available for research use only. |
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Acetyl CoA Carboxylase 1 antibody detects ACACA, a biotin-dependent enzyme that catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step in fatty acid biosynthesis. ACACA is highly expressed in lipogenic tissues such as liver, adipose tissue, and mammary gland, where it regulates lipid metabolism and energy homeostasis. By controlling malonyl-CoA levels, this enzyme also indirectly influences fatty acid oxidation, since malonyl-CoA acts as an inhibitor of carnitine palmitoyltransferase 1. The balance between synthesis and oxidation of fatty acids is tightly regulated, and ACACA serves as a key metabolic checkpoint.
Research with Acetyl CoA Carboxylase 1 antibody has revealed the enzyme's role in metabolic disorders. Elevated expression or activity of ACACA has been linked to obesity, insulin resistance, and type 2 diabetes, where excess lipid synthesis contributes to metabolic imbalance. Conversely, pharmacological inhibition of ACACA is under investigation as a therapeutic strategy for reducing hepatic steatosis and dyslipidemia. In oncology, cancer cells often upregulate ACACA to meet the increased demand for fatty acids, making this enzyme a potential target in tumor metabolism research.
Clone-based validation demonstrates that antibodies against ACACA can be applied in multiple assays including western blot, immunohistochemistry, and immunofluorescence. These reagents allow scientists to monitor changes in ACACA expression under different physiological and pathological conditions. They also provide a way to study how post-translational modifications, such as phosphorylation by AMP-activated protein kinase, regulate ACACA activity in response to cellular energy status.
NSJ Bioreagents offers this Acetyl CoA Carboxylase 1 antibody as a dependable research tool for studying lipid metabolism, metabolic disease, and cancer biology. Alternate names include ACACA antibody, ACC1 antibody, ACCA antibody, acetyl-Coenzyme A carboxylase alpha antibody, and acetyl-CoA carboxylase alpha antibody.
Optimal dilution of the Acetyl CoA Carboxylase 1 antibody should be determined by the researcher.
Recombinant human protein (amino acids D31-R2336) was used as the immunogen for the Acetyl CoA Carboxylase 1 antibody.
After reconstitution, the Acetyl CoA Carboxylase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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