ACACB Antibody / Acetyl-CoA carboxylase 2 Antibody

ACACB Antibody Overview

ACACB Antibody reagents target acetyl-CoA carboxylase 2 (ACC2), encoded by the ACACB gene. ACC2 is a mitochondrial enzyme that regulates lipid metabolism by converting acetyl-CoA into malonyl-CoA. This malonyl-CoA acts as a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1), the enzyme that controls entry of long-chain fatty acids into mitochondria for β-oxidation.

While ACC1 (ACACA) primarily supports fatty acid synthesis in lipogenic tissues, ACC2 (ACACB) functions as a metabolic “switch” in oxidative tissues such as heart and skeletal muscle, where it governs whether cells rely on glucose or fatty acids for energy. By fine-tuning fatty acid oxidation, ACC2 helps maintain systemic energy balance.

Dysregulated ACC2 activity is linked to obesity, insulin resistance, type 2 diabetes, cardiovascular disorders, and altered exercise physiology. Because of this, the ACACB Antibody is an essential tool for lipid metabolism research, translational medicine, and therapeutic discovery. The Acetyl-CoA Carboxylase 2 Antibody provides complementary detection for reproducible results across multiple assay platforms.

Why Choose ACACB Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides ACACB Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody is rigorously validated for specificity, reproducibility, and consistency.

Benefits include:

• Metabolic Specificity: Detects a regulator of mitochondrial fatty acid uptake.

• Assay Versatility: Reliable performance across tissue, serum, and cell assays.

• Reproducibility: Guaranteed batch-to-batch consistency.

• Detailed Documentation: Protocols, validation data, and suggested controls included.

• Translational Value: Suitable for biomarker research and drug development.

By selecting NSJ Bioreagents, researchers can depend on the ACACB Antibody for precision and reproducibility in metabolic and translational studies.

Applications of ACACB Antibodies

The ACACB Antibody supports broad applications across basic biology, disease models, and translational medicine.

1) Fatty Acid Oxidation and Energy Balance

• Detect ACC2 expression in oxidative tissues such as skeletal muscle and heart.

• Support studies of malonyl-CoA regulation of CPT1 activity.

• Provide biomarkers for mitochondrial fuel selection.

• Extend into translational energy metabolism pipelines.

2) Obesity and Metabolic Syndrome

• ACACB Antibody detects altered ACC2 levels in obesity models.

• Supports studies linking reduced fatty acid oxidation to weight gain.

• Provides biomarkers for metabolic syndrome.

• Extends into translational endocrinology and obesity research.

3) Insulin Resistance and Type 2 Diabetes

• Detect ACC2 expression changes during insulin resistance.

• Support studies connecting ACC2 dysregulation with impaired glucose homeostasis.

• Provide biomarkers for diabetes progression.

• Extend into translational diabetes pipelines.

4) Cardiovascular Biology and Heart Failure

• ACACB Antibody detects ACC2 activity in cardiac muscle.

• Supports studies of substrate utilization in cardiomyopathy and ischemia.

• Provides biomarkers for metabolic remodeling in heart failure.

• Extends into translational cardiology.

5) Exercise Physiology and Muscle Metabolism

• Detect ACC2 regulation during endurance training and nutrient stress.

• Support studies of skeletal muscle fuel switching between lipids and glucose.

• Provide biomarkers for exercise adaptation.

• Extend into sports physiology and metabolic performance research.

6) Pharmacology and Drug Discovery

• ACC2 is a therapeutic target for obesity and diabetes drug development.

• Antibodies validate drug efficacy in preclinical studies.

• Provide biomarkers for metabolic therapy outcomes.

• Extend into pharmaceutical pipelines.

7) Translational and Clinical Research

• ACACB Antibody supports biomarker discovery in human cohorts.

• Provides reproducibility for diagnostic pipelines.

• Ensures consistency across clinical trial assays.

• Bridges fundamental metabolism with translational applications.

Why Are ACACB Antibodies Important?

ACC2 regulates the balance between fatty acid oxidation and glucose utilization, serving as a gatekeeper of energy metabolism. The ACACB Antibody equips researchers with validated reagents to study this regulation in health and disease.

In metabolic research, it clarifies how ACC2 activity shapes obesity, diabetes, and insulin resistance. In cardiology, it highlights how substrate shifts contribute to heart failure. In exercise physiology, it defines endurance adaptations. In drug discovery, it validates ACC2 as a therapeutic target for metabolic diseases.

Clinically, ACC2 is a promising biomarker and drug target for obesity, cardiovascular disease, and diabetes. Reliable Acetyl-CoA Carboxylase 2 Antibody reagents ensure reproducibility across discovery, translational, and clinical pipelines.

Conclusion

ACC2 is a mitochondrial enzyme regulating fatty acid oxidation and systemic energy balance. The ACACB Antibody provides validated reagents for obesity, diabetes, cardiovascular disease, and translational studies, while the Acetyl-CoA Carboxylase 2 Antibody complements these applications across multiple platforms. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing metabolic biology and therapeutic research.