ACACA Antibody / Acetyl-CoA carboxylase 1 Antibody

ACACA Antibody Overview

ACACA Antibody reagents target acetyl-CoA carboxylase 1 (ACC1), encoded by the ACACA gene. ACC1 is a cytosolic enzyme that catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA, the committed step in de novo fatty acid biosynthesis. This makes ACC1 the rate-limiting enzyme for lipogenesis, controlling how cells store and generate lipids.

ACC1 is highly expressed in lipogenic tissues, particularly liver and adipose tissue, where it regulates lipid storage, metabolic signaling, and systemic energy homeostasis. Dysregulation of ACC1 activity is closely linked to obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome. Elevated ACC1 activity also contributes to cancer by supporting metabolic reprogramming and tumor growth.

Because of its central role in metabolism and disease, the ACACA Antibody is indispensable for research in lipid biology, obesity, hepatology, oncology, and translational medicine. The Acetyl-CoA Carboxylase 1 Antibody complements these applications by ensuring reproducible detection across assays.

Why Choose ACACA Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides ACACA Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous quality control for specificity, reproducibility, and assay reliability.

Benefits include:

• Metabolic Relevance: Detects a central enzyme in fatty acid synthesis.

• Assay Versatility: Validated across tissue, serum, and cultured cells.

• Reproducibility: Guaranteed batch-to-batch consistency.

• Comprehensive Documentation: Datasheets with controls, protocols, and validation images.

• Translational Value: Suitable for biomarker discovery and therapeutic research.

By selecting NSJ Bioreagents, researchers gain reliable, high-performance ACACA Antibody reagents for diverse applications.

Applications of ACACA Antibodies

The ACACA Antibody supports wide-ranging applications in metabolism, obesity, liver biology, oncology, and translational pipelines.

1) Lipogenesis and Fatty Acid Biosynthesis

• Detect ACC1 expression in hepatocytes and adipocytes.

• Support studies of malonyl-CoA production and fatty acid elongation.

• Provide biomarkers for lipid synthesis in health and disease.

• Extend into translational research on lipid metabolism.

2) Obesity and Metabolic Disease

• ACACA Antibody detects ACC1 overexpression in obesity models.

• Supports studies of adipose tissue dysfunction and metabolic imbalance.

• Provides biomarkers for obesity and insulin resistance.

• Extends into translational endocrinology.

3) Non-Alcoholic Fatty Liver Disease (NAFLD)

• Detect ACC1 upregulation during hepatic steatosis.

• Support studies of liver lipid accumulation and progression to NASH.

• Provide biomarkers for NAFLD severity and treatment response.

• Extend into translational hepatology.

4) Oncology and Tumor Metabolism

• ACACA Antibody detects ACC1 expression in cancer cells.

• Supports studies of metabolic reprogramming in tumors.

• Provides biomarkers for targeting lipogenesis in cancer therapy.

• Extends into translational oncology pipelines.

5) Diabetes and Glucose Homeostasis

• Detect altered ACC1 expression in insulin resistance and type 2 diabetes.

• Support research into lipid-driven impairment of glucose regulation.

• Provide biomarkers for diabetes progression.

• Extend into therapeutic discovery pipelines.

6) Pharmacology and Drug Discovery

• ACC1 is a therapeutic target for obesity, diabetes, and cancer drugs.

• ACACA Antibody supports drug validation in preclinical models.

• Provides biomarkers for drug efficacy and metabolic impact.

• Extends into pharmaceutical development.

7) Translational and Clinical Research

• ACACA Antibody supports biomarker-driven studies of liver, adipose, and cancer tissues.

• Provides reproducibility for diagnostic and therapeutic pipelines.

• Ensures assay consistency in clinical translation.

• Bridges basic metabolism with patient outcomes.

Why Are ACACA Antibodies Important?

ACC1 is the master regulator of fatty acid biosynthesis, controlling lipid storage, energy homeostasis, and metabolic adaptation. The ACACA Antibody provides researchers with validated tools to study this enzyme in health and disease.

In metabolic biology, it clarifies how ACC1 drives lipogenesis in obesity and diabetes. In hepatology, it highlights roles in fatty liver disease progression. In oncology, it reveals how tumor cells exploit lipid biosynthesis for growth. In endocrinology, it provides insights into metabolic syndrome and insulin resistance.

Clinically, ACC1 is both a biomarker and therapeutic target. Reliable Acetyl-CoA Carboxylase 1 Antibody reagents ensure reproducibility in biomarker-driven research, diagnostics, and therapeutic development.

Conclusion

ACC1 is a cytosolic enzyme that catalyzes the rate-limiting step in fatty acid biosynthesis. The ACACA Antibody provides validated reagents for obesity, fatty liver disease, oncology, and translational studies, while the Acetyl-CoA Carboxylase 1 Antibody complements these applications with reproducibility across platforms. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing metabolic and clinical research.