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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Von Willebrand factor (VWF) is a secreted glycoprotein encoded by the VWF gene and synthesized primarily by endothelial cells and megakaryocytes. vWF Antibody / Endothelial Injury Response Marker Antibody recognizes a protein that is closely linked to endothelial activation and vascular injury responses. VWF antibody, also referred to as von Willebrand factor antibody, is widely used in studies examining how blood vessels respond to damage, inflammation, and stress.
Endothelial injury triggers a cascade of biological responses, including activation of endothelial cells, release of stored mediators, and changes in vascular permeability. VWF plays a central role in this process by being rapidly released from endothelial storage granules upon stimulation. This release reflects an immediate response to vascular disruption and contributes to platelet recruitment and hemostatic regulation.
Because VWF release is closely tied to endothelial activation, its detection can provide insight into the presence and extent of vascular injury. In tissue sections, staining patterns may highlight areas where endothelial cells are activated or where vascular structures are responding to stress. This makes vWF Antibody particularly useful for identifying regions of vascular response within complex tissue environments.
In addition to its role in acute injury, VWF is also involved in chronic vascular conditions where ongoing endothelial activation contributes to disease progression. Detection of VWF in these settings can help reveal patterns of vascular involvement and provide context for tissue-level changes associated with injury and repair.
Although VWF is widely used as a general endothelial marker, its behavior during injury provides additional functional insight. The ability to detect both endothelial presence and activation-related changes makes it especially valuable in studies of vascular response biology.
vWF Antibody / Endothelial Injury Response Marker Antibody is particularly well suited for investigations focused on vascular injury, endothelial activation, and tissue response to damage. By highlighting a protein that is directly involved in endothelial response pathways, it supports analysis of how blood vessels react to stress and maintain vascular integrity under challenging conditions.
The optimal dilution of the vWF Antibody / Endothelial Injury Response Marker Antibody for each application should be determined by the researcher.
Amino acids 1815-1939 from the human protein were used as the immunogen for this vWF Antibody / Endothelial Injury Response Marker Antibody.
Store the vWF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
VWF endothelial injury antibody, vascular injury response marker, vWF endothelial damage antibody, vessel injury marker antibody, VWF injury response antibody
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